I am homozygous MTHFR A1298C, and have had 4 miscarriages: the first at 5 W; the second was a twin pregnancy (miscarriages at 9 W and 12 W); the last at 7 W. Now I take baby aspirin, folic acid and vitamin B, but when I will be prengant I must take eparin. I have many others mutations: Pai I 5g/5g; HPA 1 1a/1a; ACE del/del;F XIII homo V34L; Beta Fibr. Hetero 455G>A. Fibrinogen (now): 11,8. I 'm a little positive to ASMA (1:40), and I have, sometimes, erythema, so i take also prednisone. I'm sure that I find causes of my miscarriages, but I'm searching for studies or news/statistics about my situation, specially about mthfr homo A1298C, because there are many confusion ...So I ask: Is my condition actually miscarriage's cause? There are riscks for my health when I will be pregnant again?
Thank you.