Started Rebif almost a month ago (after being on Avonex for over a year, blah) and this week has come and gone and Aunt Flo is absent this month. Now since I was 12 there have only been a handfull of times this has happened: Getting pregnant with child #1 and Child #2 and also there was a 3 month time frame in 2007 (in the summer leading up to my initial flare up). Also my tubes have been tied, burnt , you name it it was done.. My surgeon told me it would be an act of God if I ever get pregnant again, I could be but the cheapo preggers test says NEGATORY. So that leaves two choices (for now); Either the Rebif is causing the Amenorrhea or i'm going back into one of these relapses of extreme fatigue, painful and without a menstrual cycle.. Any one elsehaving issues with Rebif and their woman issues?? Sorry it's late at night and I've taken my meds ... lol