I'm looking for a little help researching anaphylaxis reaction with recombinant interferon beta 1a. I don't need the amount of cases in the reporting or if it has happened. I'm more-so seeking clinical/scientific case reports that discuss various testing mechanisms when hypersensitive or anaphylaxis reactions were though to be cause by the interferon.
Reason I'm asking is because my allergist has been doing some digging in order to develop a type of protocol to perform the challenge on me. She has not received any guidance from the company. She has asked me if I could get the 44 mgs and they would inject it under the skin, but they would also use some other solution I think, but am not sure exactly how they are going to do it and don't know enough about this type of testing and false positive results, etc.
I'm excited that there is a possible plan that may tell the tale of what med caused my reaction, but am also concerned that she was only able to find 2 articles. Good thing is the articles are ref. 2 people who did develop a reaction after 6 months. One was skin necrosis, the other anaphylaxis. I told her I would send anything I find to supplement her efforts.
My time to dig is limited as is probably the case for most of you too, but thinking if even a couple of us can hit the literature in the field, we may come up with something additional to send her.
Some of the words I've played around with for searches are: Rebif, interferon mediated reaction, anaphylacod reaction rebif, recombinant interferon beta, IFN
I know case studies are the way to go for this. As some of them may, I pray, may discuss skin testing of different preparations or components of preparations.
Please tell me if I've not described what I'm looking for very well. Been crazy busy these days to say the least.