Avatar universal

Could this be MS

I have had severe weakness in my legs and feet with pain/cramps. My calf muscles are the worst.I will also mention that I had a CT show lesions on my brain and blood work showed increase in my adolase enzyme. My symptoms have gotten worse as the days progress.it is really hard for me walk and I have become very fatigued. There is also a family history of chronic inflammatory Polyneuropthy
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Avatar universal
I should also mention that the muscles in my arms and thighs  feel like I've over exerted my self but I have done nothing to warrant that kind of feeling
987762 tn?1331027953
Hi and welcome,

You mention your blood work showed increase in your Adolase enzyme, Aldolase is an enzyme that helps convert glucose into energy, when aldolase levels are elevated in the bloodstream it is usually a sign of muscle or liver damage, from my understanding though it can also be falsely elevated by the amount of physical activity you did prior to the test but when it is muscle it's generally associated with conditions related to skeletal muscle damage.....technically with neurological conditions like MS the muscles themselves are not actually damaged like what happens with the conditions effecting the peripheral nervous system.

Some neuropathies are hereditary but you've not mentioned the typical tests that would indicate there is or isn't nerve or muscle damage (eg peripheral nerve conductor tests EMG, NCV, brain or spinal MRI's, LP, neurological assessment etc) or if the brain lesions found on your CT were suggestive or consistent with deymelinating conditions in someway to warrant further investigation. The finding of a "white matter lesion" in the brain during a CT or MRI is quite common, and depending on their location, size, shape, number etc they are typically incidental findings of very small 1-3mm ischaemic white matter lesions and not suggestively abnormal.

"A variety of medical conditions and other factors can cause polyneuropathy, including:

Diabetes: This can be a significant risk factor, especially if blood glucose levels are poorly controlled. One study of more than 1,400 people with type 2 diabetes found that every fifth person had diabetic neuropathy.

Alcohol abuse: Alcohol can damage nerve tissue, and alcohol abuse is often associated with nutritional deficiencies that contribute to neuropathy.

Autoimmune conditions: The immune system attacks the body, causing damage to nerves and other areas. Conditions include Sjogren's syndrome, celiac disease,

Guillain-Barré syndrome, rheumatoid arthritis, and lupus.

Bacterial or viral infections: Certain infections can lead to neuropathy, including

Lyme disease, shingles, hepatitis B, hepatitis C, and HIV.

Bone marrow disorders: Examples of these include abnormal proteins in the blood, some forms of bone cancer, and lymphoma.

Exposure to toxins: Toxic neuropathy may be caused by exposure to industrial chemicals such as arsenic, lead, mercury, and thallium. Drug or chemical abuse is also a risk factor.

Hereditary disorders: Certain conditions, such as Charcot-Marie-Tooth disease, are forms of hereditary neuropathy.

Hypothyroidism: An underactive thyroid may lead to polyneuropathy, although this is uncommon.

Kidney disease: Uremic neuropathy is a form of polyneuropathy that affects 20 percent to 50 percent of people with kidney disease, according to the Center for Peripheral Neuropathy.

Liver disease: Research indicates that peripheral neuropathy is very common in those with cirrhosis of the liver.

Medications: Chemotherapy, along with some drugs used to treat HIV/AIDS, can cause neuropathy.

Poor nutrition: Deficiencies of vitamins B-1, B-6, B-12, and E may lead to polyneuropathy, as these are vital for nerve health.

Physical trauma or injury: Repetitive motion such as typing, accidents, or other injuries can damage peripheral nerves.

Some cases of polyneuropathy have no known cause. These are known as idiopathic neuropathy."

It's bilateral, both upper and lower (feet, calves, legs and arms) which is more suggestive of peripheral nervous system than conditions effecting the central nervous system which MS is....To be honest i don't think the tests you've mentioned are not enough to point towards what could be causing what you've been experiencing, i'd suggest you ask your primary physician what tests you still need to determine what is more likely causing these types of symptoms.

I hope that helps.......JJ
Avatar universal
Thanks Supermom_ms,
I have nerve test next month and a MRI was just done Friday, I'm hoping to find answers soon, as far as physical activity goes I can not do a lot right now, going to work has even been hard, I was tested for lupus, rheumatoid arthritis, hep B, celiac disease, and a few others that were ruled out. My hemaglobin, and hematocrit we're a lil high. Thanks for the suggestions
Avatar universal
Also the CT revealed many lesions but that's all I was told. The nerve test will reveal any nerve damage from my understanding, right?
987762 tn?1331027953
i just lost a long post grrrrrrr sorry i can't redo it, basically if you have an issue effecting the peripheral nervous system general nerve tests should pick it up but even if your tests come up as normal that will still help narrow down the type of conditions it could be....JJ
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