Recently my left leg has been feeling weak, almost like someone is laying on it from the knee down to my toes. I take my Avonex shots in my legs, alternating each leg each week. Last night my shot was due to go in my left leg. The minute my husband cleaned the area on my thigh with the alcohol my leg jerked from the cold. I had a bad feeling that there was going to be a problem giving me the shot there. i was holding onto my son, getting ready and the minute the needle hit my skin my whole leg jumped, i knocked the needle off and my husband had to grab unto my leg to hold it still to give me the shot, I was screaming from the pain. My poor husband and son, I scared the **** out of them. I have never had that happen to be, my leg has never been that sensitive to cold/heat or touch. After that my leg kept jumping from the slightest touch. Its not to bad now, but it was unexpected since my leg has never been this sensitive to anything. Anybody have this happen to them? I would imagine that if this happens again (meaning the sensation due to touch or the cold from the alcohol swab) I will move the shot to my backside when I am working on the left side of my body.