Overnight, my severe neuromuscular symptoms suddenly started October 2004. I was in perfect health, no problems. In two months, I was in an electric wheelchair. I have hourly relapses, monthly progression, and no diagnosis. June 12th, back of my head, left side, four hours, I had such severe pain that I would have shot the first person who walked in the door. I never had anything like that before. I have a high tolerance for pain but this was like I was being sharply jabbed with an icepick, real bad. Twice in two and a half years, right side of brain, 48 hours each, I had severe pain, not migraines, but it felt like someone was taking a knife and stabbing me over and over again. Does MS cause such severe head pain? All of my MRI's have been negative so it isn't a stroke or TIA or cancer. One time, entire right side of head, as if you divided my head in half, the scalp was extremely sensitive to touch, 48 hours. Do lesions ever cause symptoms? (but no lesions can be found on my MRI's) I remain positive but I am largely homebound, often bedridden, and no doctor knows what is going on. However, I have 100% of the symptoms of Progressive-Relapsing MS, without diagnosis. I have had several neurologists who stated "I give up", expressing extreme frustration at me. Can MRI's be flawed?