Here's the REVISED timeline/summary I prepared for the neurologist on Thursday. I guess this indicates that something autoimmune is going on, at least. Too much info? Sorry this is long...
Sally Clark – Summary at July 2007, 37 YO Caucasian Female, DOB 4 Sept 1970.
Bloodtest Results - 2007
Date Test Result Range
22 Jan 07 FT3 2.03 2.8-7.1 pmol/L
FT4 10.58 12-22 pmol/L
TSH 0.573 0.27-4.2 mIU/L
(Following this result increased t4 by 50 mcg/day).
12 Feb 07 Total Protein 73 66 – 87 g/L
Albumin 45.8 34-48 g/L
Globulin 27.2 32-39 g/L
Creatinine (F) 75.52 45-84 umol/L
SGOT (F) 29.6 up to 32 U/L
SGPT (F) 27.5 up to 31 U/L
Prolactin 436.2 102 – 496 uIU/ml
Potassium 4.4 3.5-5.0 mmol/L
7 April 07 FT3 5.01 2.8-7.1 pmol/L
FT4 13.81 12-22 pmol/L
TSH 0.039 0.27-4.2 mIU/L
11 June 07 OGTT FBS 5 3.89-6.38mmol/L
OGTT 1st Hr 5.1 < 9.2
OGTT 2nd HR 4.5 < 7.7
OGTT 3rd Hr 4.1 1.68 mmol/L
LDL 1.70 1.56-4.55 mmol/L
VLDL 0.35 0.25-0.79 mmol/L
FT3 4.49 2.8-7.1 pmol/L
FT4 16.58 12-22 pmol/L
TSH 0.023 0.27-4.2 mIU/L
Prolactin (F) 579 102-496 uIU/ml
LH (luteal) 8.75 1 – 11.4
FSH (luteal) 3.95 1.7 – 7.70
Estradiol (luteal) 67.01 43.8-211 pg/mL
8am Cortisol 278.3 171 – 536 nmol/L
15 June 07 Vitamin D 220 47 – 144 nmol/L
iPTH 56.3 12 – 72 pg/mL
Antithyroglobulin ab < 20 (negative)< 40 IU/ml
Antimicrosomal antibody Negative
Anti-TPO Antibody 26.9 (negative)<35 IU/ml
6 July 07 Serum Ferritin 13.02 6-81 ng/ml
6 July 07 Serum Transferin 234 212-360 mg/dl
Serum Vit B12 312 223-1132 pg/mL
Other Diagnostics 2007
- Chest X-ray clear
- Testing for & diagnosis of asthma
- Repeat MRI: showed Microadenoma, white spots.
Current Medications at July 2007
1. Dessicated thyroid 125 mcg + Thyroxine 100 mcg (adjusted 23-7-07)
2. Parlodel ½ tablet / day (at bed time) (started July 07)
(Nausea ongoing & bothersome side effect).
3. Vitamin B12 oral (500 mcg x 3/day) (started July 07)
4. Antihistamine (celestamine), 1 tab 2pd, and as required to manage symptoms (dosing changed from as required (Jan 07) to 2/day in July 07).
5. Symbicort – 2 dose/day (since Jan 07)
6. Ventolin – as required & before training session (since Jan 07)
1992 Consult with rheumatologist for back and joint pain (wrist / hips).
No specific findings. No treatment. Suggested it was psychosomatic.
1995 Lived and studied in China.
End 1995 Moved to Hong Kong to start work with environmental company.
1996 Shingles attack, treated with antiviral meds.
1997 Moved from Hong Kong to Philippines (for work).
1998 ER visit for kidney stones. Pain killers given. Resolved without treatment.
1999 Consult Gastroenterologist for reflux, hyperacidity, abdominal discomfort.
Diagnosis Gastritis. Use PPIs, antacids, Motilium. Symptoms continued.
1998-1999 Rapid weight gain despite diet and regular exercise (tennis, gym).
Progressive fatigue, depression, exercise intolerance. Disrupted menstruation.
Mid 2000 Weight up to 210+ lbs. Severe symptoms. Finally diagnosed hypothryoid, polycystic ovarian syndrome, IBS. Treatment levothyroxine, continued PPIs, Diane 35, metformin. (stopped Diane 35, Metformin, PPIs after about 1 year).
Parathyroid problems with elevated iPTH, low calcium? Treated with calcitriol (calcium and iPTH levels returned to normal after about 2 years and discontinued calcitriol).
Gastric symptoms continued – but improved with thyroid treatment. Continued with diet and exercise. Weight loss progressed.
Mid 2004 Commenced triathlon activities. Weight about 165 lbs.
Continuing stomach problems. Chronic D-C. Nicknamed “El Cubetta” – “the toilet” by triathlon team mates.
Muscle cramping on-going problem –particularly in swimming. Improves a little with continued conditioning.
Thyroid med dose adjusted up.
Sept 2004 MRI subsequent to continuing long-term galactorea. Pituitary microadenoma noted. Started on parlodel. Discontinued due to side effects (after about 6 months).
Mid 2006 Father in Australia died from skin cancer (after 6 year battle)…
Started desiccated thyroid (about July 06) – assist with symptoms particularly mood and energy.
End 2006. Training for Iron-Man. Tummy problems dramatically worse – daily chronic D, bloating, reflux, belching, pain (affects training).
Chronic non-productive cough.
Dec. Consult Gastro – Endo/Colonoscopy carried out. Diagnose IBD from colonoscopy biopsy, no endoscopy biopsy carried out. Pt. declined medication. Decided to trial gluten free diet (based on family history). Near complete resolution of gastric symptoms with diet change and strict adherence to GF diet. Symptoms recur if gluten is eaten.
4th qtr - first notice visual symptoms: flashes of light, movement in peripheral vision. Intermittent only. Occasional base of skull headaches.
Early 2007 Consult allergy asthma dr. (Dr. De Vera) Asthma diagnosed. Started steroid inhaler & ventolin as required.
Itching continues – low back, trunk, face.
Skin allergy testing +ve for rice, chicken, mango, tilapia, fish paste, dust mites. Systemic response to allergy testing & was treated with oral steroids. Prescribed daily antihistamine.
Have not done strict elimination diet yet, but initial testing seems to have fluctuating & non-predictable allergy response (ie. Itchy one day from eating something, no response the next day).….
Feb 2007 Completed first Ironman Triathlon in 16:45. Good experience. Want to do it again.
June 2007 Repeat MRI: Microadenoma, white spots.
Mid 2007 Weight about 150 lbs.
Visual symptoms become much daily event.
Strange sensations: occasional feeling that face is numb (in places), prickling sensations (over head), burning sensations in legs. Base of skull headaches more frequent. More tired than usual / concentration poorer. Delayed training recovery compared to teammates. Often catch feet when walking (shoes?? Lazy?? – Don’t usually wear heels)… am famous for bumping into things / dropping things / being clumsy… disassociated from body feelings…
Itching symptoms (not daily).
Muscle cramping much worse during swimming / after training / even at rest.
Doctors: Endocrinologist: Dr. Mike Villar
Asthma Dr.: Dr. De Vera