BET GLOBULIN?????

[chump]

I HAVE A QUESTION FOR ANYONE WHO KNOWS ABOUT THE CSF TEST AND EXACTLY WHAT IS THE DIFFINETIVE READING THAT CONSTITUTES A +MS DX.THE ONLY ABNORMALITY ON MY FLUID WAS THE BETA GLOBULIN AND IT WAS SLIGHTLY ELEVATED.

[BobbHilton]

Hi,
   MS is a clinical diagnosis, and the labs are supportive only , so CSF abnormalities supporting a diagnosis of multiple sclerosis:
1-Oligoclonal bands and/or
2-An increased IgG index

Beta or gamma globulin, myeline base protien, tau protein, GFAP protein are believed  to originate from the brain (not coming with the blood from the body) and do not add any thing to diagnose or rule out MS according to the new criteria of MS.

   Its a very big topic , but I think this simplification could answer your question.

    Bob

[chump]

SO THE ALL IN ALL DX FOR MS IS SYMPTOMS,???CSF, AND A FEW LEISONS ON THE MRI.? SO IF THE OLI BANDS ARE WITH IN NORMAL LIMITS THEN WHY WHEN THE BETA GAMS ARE ABNORMAL WOULD THEY BOTHER SENDING THEM TO ANOTHER LAB FOR ELECTROPHORISIS IF IT IS FROM THE BRAIN NOT THE BLOOD. AS YOU CAN SEE IT IS CONFUSEING AND I GUESS A LITTLE DENIAL ON MY PART.I GUESS I DON'T WANT TO THINK OF MS IF THERE IS NO DEFINETE PROOF .I THOUGHT CSF WITH MRI WAS THE PROOF.IF THE OLI BANDS WERE WNL MAYBE I DON'T HAVE MS????

[BobbHilton]

your Q was how to Dx MS.. ..but if you want to know about betaglubin then its 2 typs
-Beta1 globulin  " Fishman RA : CSF of the nervous system. 2nd Edition, WB Saunders and Co., Philadelphia. 1992; 189-333 ...which says clearly that The relative concentration of beta-1 globulins is somewhat higher in normal CSF than in serum. However, no specific correlations with neurological diseases have been established with regard to these proteins!!!.

BUT,there is one report on beta-1 globulins (An older one 1973), where raised levels observed during exacerbation of MS. The authors reported that these may be due to release of the protein as a result of demyelination during an exacerbation or due to increased synthesis within the CNS. There is no other reported work describeing changes of beta-1 globulin in MS (Olsson JE, Link H : Immunoglobulin abnormalities in multiple sclerosis. Arch Neurol 1973; 28 : 392-399.)


-About Beta-2 globulin
its been used to look for neurosyphilis and Behcet's diseas which may mimic MS

  Bob