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Can CADASILs take Benadryl

Benadryl info says it has an "anti-cholinergic" effect.  CADASIL info says it has a cholinergic aspect to the disease.  With chronic sinusitis resulting in post-nasal drip, contributing to possible COPD in the form of very mild persistent bronchitis, would taking Benadryl contribute to the symptoms of CADASIL?  I did read that the active substance in Benadryl is often used in conjuction with other drugs for relaxation/sleep issues, but there seemed to be a warning not to use it with patients with dementia (not at that stage yet, of course).  

By trying to solve one problem, am I creating another in the possibility of increased cognitive impairment, and earlier onset of CADASIL symptoms?
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