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Re: Denervation
Posted By George on November 27, 1998 at 17:02:42:

In Reply to: Re: Denervation posted by CCF neuro MD MM on November 26, 1998 at 21:09:22:

Thank you for your fast answer.
I have a couple more questions I hope you can help.
In the case of ALS would you expect the EMG to pick up denervation in a few or several muscles or in one muscle only.
If the EMG picks up denervation in one muscle only and there has been no clinical progression in several months, what are your thoughts....

The first question is difficilt to answer but denervation is probably
happening for several months before the symptoms become obvious.
Denervation occurrs piece by piece within a muscle, not as one proces involving
the entire muscle sinultaneously.
The EMG picks up the fact that some muscle cells are already denervated.
fasiculation occurrs in a group of muscle cells after they have been
One can maximise the potential of a muscle group by training the fibers which
have not been denervated, this would probably manifest by a slower rate of
devevelopment of weakness than would otherwise have been the case, but it
will not halt or reverse the development of weakness.

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