I understand that amyloidosis is a neurological condition and that an enlarged tongue can be a symptom. What are the other symptoms of this disease and is the onset of the disease slow or does it advance rapidly? Are fasciculations a common symptom? Muscle weakness? Thank you for your help.
Amyloidosis is in fact a multisystem disease which sometimes may effect the
nervous system. It involves the deposition of protein aggregates in various
tissues and can be either a genetic condition or may occurr in response to
another pathological condition,for example chronic inflammation.
The age of onset and progression of amyloidosis is largely dependent on
the underlying cause with more rapid evolution in the familial (inherited)
types. The neurological manifestations usually declare themselves in
the form of peripheral neuropathy, with numbness and weakness of the peripheries.
The major problems tend to result from deposition of amyloid in opther
organs including the heart, bowel and kidneys. deposition in the tongue is possible.
Muscle weakness is frequent and fasiculations are possible in any condition where
the peripheral nerve supplying a muscle is damaged.
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