clonus in right leg, motor neuron disease

[Roni14]

Last 8 months have had clonus in right leg, losing muscle strength harder to walk. Have had brain mri, report said signs of als, 2 spinal mri all normal, went to U of M for test and EMG, which showed both upper and lower motor neuron signs in right lower extremity and changes in paraspinals and left lower extremity. Had tons of blood test all normal. So just the the one MRI and EMG showing signs of anything. But, know one knows, I did have gastric bypass surgery 4 years ago. Low iron 3 years ago, with iron iv's been normal since. My question is think at this time there watching to see if gets worse every 3 months now. Or what to do from here. This not knowing where to get answers at this point. Does this sound like it is heading in the ALS direction?  Thank you, for your time!

[rolling with the punches]

HELLO EVERYONE,
I WAS WONDERING IF ANY ONE HAS BEEN SEEING FLASHES OF BRIGHT LIGHT IN BOTH EYES AT THE SAME TIME. MY MRI SHOWS A GULF BALL SIZE MASS IN THE FRONT LOBE OF MY BRAIN. I WAKE UP DAILY WITH A HEADACE IN THE CENTER TOP OF MY HEAD WHICH LESSENS AS I GET UP.
I FEEL DELAYED FEELINGS ON EVERY LEVEL INCLUDING SEX. ONE CASE OF BLACK OUT FOR SECONDS. SPEACH TURNING SOMETIMES BACKWARDS.
ONE ASPECT IS NO FEAR OF ANYTHING BUT WANTING TO DO THE RIGHT THING FOR MYSELF. ANY COMMETS

[CCF-Neuro-M.D.-PW]

I cannot give you a clinical diagnosis over the internet unfortunately. It may be beneficial to see an ALS specialist at a certified ALS center such as the Cleveland Clinic (Dr. Eric Pioro)) to ascertain whether you have ALS or not.

The El Escorial criteria for ALS (international consensus criteria for diagnosis) say that for definite ALS you have to have symptoms (either clinical or EMG) of ALS in 3 limbs or bulbar (swallow etc). If only in one leg you would qualify for a criteria of possible ALS.

There are other causes of upper and motor neuron signs in the legs such as diabetic neuropathy, syphilis of the spinal cord, a combined peripheral neuropathy and spinal cord/brain lesion, Friedrichs ataxia (it does not sound like you have this) , B12 deficiency and ALS. Which one it might be could be best sorted out by the specialist.

ALS is generally not diagnosed by brain MRI - there are no clear diagnostic criteria, so it is controversial to diagnose ALS by a brain MRI (although we know there are changes on a microscopic level in teh brain)

[motheroftwo]

Usually MRI in als doesn't show any abnormality until the late stages, but in many people the MRI doesn't show any abnormalities at all through out the disease.

Ive had als for 5 yrs, I had a third MRI a few months ago it came back normal.

Good luck.