I need to know if regrowth of dopamine receptors is possible in humans in the frontal cortex, striatum, hypothalamus, nucleus accumbens if they were all destroyed somehow by a contaminated illicit substance, which caused total fixed insomnia, complete anhedonia throughout the limbic system, and bad tinnitus.
4 months later of which no recovery was evident other than a little bit of cognitive recovery.
There was initially a little body movement abnormality which improved over a month.
Vascular tone, cns shutdown / possible damage added to this through supposed amyl nitrate use. Which has moderately recovered, leaving vascular tone issues in the legs and possible dopamine reduction also as well as damage to serotonin transport, which seems partially recovered.
There seems little to no recovery of dopaminergic function in the limbic system.
The fixed insomnia is a real physical symptom, not imagined, and there seems questionable possibility of dopaminergic recovery from complete destruction.
The substances which caused this are not entirely known for certain.
It is assumed 5-htp powder, and cocaine, meth or Mephedrone with contaminant at a dosage of 10grams within 24hr period. Caused intense brain stem damage, resulting In depression, loss of mental facultys, tinnitus and brief serotonin syndrome upto 2hours after. Then over the next 12 days there was a gradual loss of dopaminergic transport resulting in complete anhedonia, loss of male brain orgasm.
One month abstinence from all substances resulted in no recovery.
After this month of abstinence 3grams of intranasal crystal substance was consumed along with one large inhaled dose of amyl nitrate. This caused complete destruction of ability to sleep which persists 4months later along with previous mentioned symptoms.
Is there any chance of identification of contaminants. Or would the suggested substances cause described effects at reported dosages?
If there is no recovery of dopaminergic function 6months after the events, what is the reality of transplantation of dopamine receptors into the striatum, nucleus accumbens, and frontal cortex, hypothalamus for recovery of sleep function and orgasmic ability as well as brain function recovery.
In rats, if over 90% of dopamine receptors are destroyed there is no recovery.