. By Lasie74 | Feb 02, 2013
I have been suffering from various non specific symptoms for long time but no definite diagnosis has been made in the context of global picture of symptoms and abnormal lab findings. They are as follows:
Positive ANA with speckled and nucleolar pattern
Positive atypical P-ANCA
Elevated Kappa light chain
erratic blood level of triglycerides from normal to slightly elevated to very high. (no medications)
Chornic skin rash on the side of neck and at the base of head and neck for almost seven years. No treatment has cured it.
Skin biopsy showed acanthotic psoriasiform dermatitis, infiltration of leukocytes looking like lichenified ezema
Difficulty with thermoregulation and severe anhidrosis, hyper-keratinization
severe damage of Post ganglionic sudomotor sympathetic fibers causing autonomic neuropathy diagnosis of sjogren.
fleeting pains and aches, inflammatory arthralgia
mucosal lesion which are very painful in mouth and vagina
above problems occurred after uterine fibroids were removed and blood transfusion was received
After blood transfusion, positive for CMV and EBV (only one partner)
short sun exposoure causes unexplained severe fatigue, permanent pigmentation rash and swelling of feet and hands without pitting edema.
QSART test positive for unmyelinated post ganglionic fibers damage
rapid transition on barium swallow test to rectum in only 15 min instead of an hour.
Severe blurred vision off . Slit lamp exam confirmed punctate cornea. Cyst formation tendency. ganglionic cyst removed. ovaries have some mass or cyst or dermoid cyst
rapid loss of hair, testosterone very low
niacin abnormal.unexplained sweating on face and neck only at night even when it is a freezing temperature.
ppd test positive
rare side effects to medications like INH, phenothiazine group, benadryl. demrol, metronidazole and niacin. My research showed all these chemicals have a common thread of having aromatic ring with N and their metabolism is through hepatic Cytochrome P450. Rare side effects experienced were blurred vision, dizziness, loss of appetite; oral dystonia invloving tongue; paradoxical effect, insomnia; its metabolites related symptoms (due to is prolonged half life); dizziness; severe hypotension (blood pressure dropped to 80) and developed rash on arms.
Severe hypoglycemia in the middle of night, causing palpitation, hunger pangs and urge to eat food like banana
Question for : paraneoplastic pemphigus, carcinoid, lymphoma, insulinoma, autoimmune hepatitis, pancreatitis, systemic lupus or mixed connective tissue disorder, autoimmune autonomic ganglionopathy, polycystic ovarian disease, or any cause due to underlying infections.
Precipitating factors: Emotional and psychological distress caused by victimization multiple times; blood transfusion and post hysterectomy. No family history, no social history no smoking no drinking. No other coexisting medical conditions