Hi, I am a 36yr old female-15mnths ago, started having pins and needles in feet, then burning in legs then hands and arms, loss of appetite, fatigue-July 06, lower left leg numb for 6hrs. Sept'06, blood tests showed B12 at 101. Shillings test showed Pernicious Anemia. Nov 06, lost feeling in left side of face, couldn't squeeze with left hand and couldn't feel pinprick on left foot, also reflexes absent. At times, I lose strength in left leg and can't move left hand/arm very well. Have pain in face, mostly left side. Also, have feeling like my toes and legs are "wet" when they're not. (and sometimes like water running down my leg). I lost control of my bladder once, and skin "hurts". Also, get dizzy when standing up. Had MRI of my head, CT of chest, xray of back and left leg, ultrasound of abdomen, blood tests to rule out Celiac, Lyme, heavy metal poisoning, upper GI series, NCV, all normal. May 07, neurologist diagnosed subacute combined degeneration of spinal cord, but wants MRI of spine. I had symptoms for at least 6mnths before treatment (1 shot/wk for 5 wks, then mnthly). It's been 10mnths since I began shots, and still have burning pain in left leg. I am on 600mg Neurontin 2x daily, and take morphine for the pain (tried Lyrica but couldn't tolerate side effects). Also have twitches, and feet cramp-mostly left side. I have read that damage can sometimes be permanent-in your experience, could this be something progressive like MS, or do I just need more time?