Hi there. Duloxetine is used to relieve nerve pain or peripheral neuropathy in diabetics. so it must have been prescribed to you since you have nerve pain. it is a serotonin norepinephrine reuptake inhibitor SNRI that works by helping to restore the balance of certain natural substances in the brain. it may actually improve your mood, sleep, appetite and energy levels, and decrease nervousness. so it doesn’t look like due to the drug. I would suggest Complex Regional Pain Syndrome or reflex sympathetic dystrophy. Complex regional pain syndrome CRPS is a chronic progressive disease characterized by severe pain, swelling in the skin. There are two kinds based on presence of nerve lesion following the injury. Type I does not have demonstrable nerve lesions. Type II has evidence of obvious nerve damage. The cause of this syndrome is unknown and could be precipitated by injury and surgery. There have been cases with no demonstrable injury to the original site. spontaneous pain or pain from a stimulus as light as touch, which would not provoke pain normally, not limited to the territory of a single peripheral nerve and disproportionate to the inciting event are characteristics. Discuss this with your neurologist who will decide the best course of action. Take care.