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B6 toxicity

Hello:

I just discovered that I am B6 toxic. Ironically, I have all the symptoms of B6 deficiency, including hair loss, dermatitis, brittle nails instead of toxic neurologic symptoms. Has anyone heard or expereienced this? Thank you.

Laura


This discussion is related to vitamin B6 toxicity cause?.
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Avatar universal
if you have high levels and you are not taking supplements, the most likely problem is the MTHFR Gene that can easily be detected on a 23andMe Genetic Test done using a simple mouth swab.

The MTHFR gene is extremely common and can lead to a problem processing the B Vitamins, making people particularly susceptible to deficiency of B12, folic acid, and Vitamin B6. Ironically, in these cases, Vitamin B6 Levels and Vitamin B12 Levels will be HIGH, despite actually being a DEFICIENCY of these vitamins. This is because the vitamins build up in the bloodstream, where they are measured, but the vitamins can't get into the cells where they are needed.


“The finding of high vitamin B6 levels is consistent with
recent reports of low levels of [Vitamin B6].
Because of this, the solution to Vitamin B6 Toxicity in those who are taking no or little Vitamin B6 is to get tested for the MTHFR gene, and if positive, they will need to actually supplement with high doses of B Vitamins, despite having high levels, but in the proper forms that can be processed by the body.










In the case of Vitamin B6 toxicity, the ‘active’ form of Vitamin B6 known as P5P, also known as pyridoxal-5-phosphate. While in the case of Vitamin B12, the active form is known as Methylcobalamin B12. These forms are able to be processed by the body so that they get into the cells where they can be utilized for body processes.

Ironically, high B6 levels in blood will decrease and return to NORMAL when sufficient amounts of P5P are taken to remedy the deficiency.  The solution to Vitamin B6 Toxicity if you have the MTHFR gene is to stop getting the synthetic forms of B Vitamins, and get the proper active forms the body requires, like that present in a P5P supplement, Methylcobalamin B12, and a MTHFR Safe Multivitamin and Mineral Supplement.


Next --->
Methylcobalamin B12 --->

I'm new here and have struggled with Tue same issues as many of you luckily I go into intense research mode when trying to find answers to issues even doctors and neurologists can't figure out. I know this thread is old but hopefully this information is as helpful to you as it was me. I have experienced success with this info even though you would never think if you have toxic B6 levels you may actually be deficient in B6 as a result of being unable to properly absorb or excrete b6 which leaves you overloaded with unusable b6 and in turn may also experience the inability to absorb magnesium which causes a whole host of issues and probably the more important b6 role of building proper Gaba neurotransmissions and resulting in Gaba deficiency which also creates even more problems, the link also provides information on a gene called MRTHA which if present can cause this paradoxical event to take place, however if you can't afford genetic testing you should be able to piece it together after looking into Gaba deficiency, Magnesium absorption issues and deficiency along with if you feel like you rapidly change between B6 toxic/Deficiency symptoms. Also if possible have all of your main B vitamins checked in a blood test and keep track of your B12 and folate levels usually your B12 will also be high even if you are not adding any B Vitamin supplements.

Helpful - 1
Avatar universal
I have not heard of a B-6 toxicity. I have heard of deficiency symptoms, but never the other. How much had you been taking. You see, B-6, along with other B vitamins is water soluble, and your body excretes what it does not need, so, this is very new to me.
Helpful - 0
757137 tn?1347196453
How much B6 were you taking? And for how long? You could only develop toxicity from overdosing on supplements. If you weren't taking high doses, then the test may be wrong. I do remember a warning about about taking too much B6 and the danger of toxicity, but since this was part of a general conversation and not related to my own vitamin regime,I don't remember the details.
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Avatar universal
If you haven't already stumbled upon it, the MedHelp forum has a long discussion of B6 Toxicity here:
http://www.medhelp.org/posts/Nutrition/B6-Toxicity/show/2642
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Avatar universal
Just wanted to let you know that you are not the only one that had hair loss with b6 toxicity. In my opinion, the word needs to get out to the public that high dose b complexes should NOT be taken....ever.
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Avatar universal
Explain B6 toxic.  Since it's a vitamin, the body can't survive without it, so I assume you mean you have an excess, which usually manifests as B6 neuropathy.  It's rare, and generally temporary, but for some it can be long-term.  But B6 toxic?  What exactly does that mean?
Helpful - 0
Avatar universal
That is great information, thank you, I was diagnosed with B6 toxicity last year. I was severely nauseous when I ate foods with protein or fat. I lost 18 pounds. I forgot words while I was talking, couldn't sleep well, and my nails were weak and brittle. My feet feel a little numb, like they're about to cramp.
The symptoms slowly went away after I stopped all vitamins, especially after I went to a spa with a sauna and hot and cold pools.
Lately though my symptoms are back. I'm wondering if I drank too much Kombucha. Very discouraged about this returning. Just had more blood work, I see my doctor Tuesday. I'm going to ask her about that gene, my cousin has part of it? I can't remember what she said.
Anyway, I'm not done with my journey yet but the sauna and cold pools seemed to help detoxify.
Any other info would be helpful.
Helpful - 0
Avatar universal
Hi how are you feeling? Any news?
May I ask how much Vitamin b6 did you take and for how long? I started taking it 3 weeks ago and in a coulpe days I started feeling tingling in hands and feet, brain fog, weekness and was hard to walk after a week of taking it. I stopped 7 days ago and then it felt a little better for 2-3 days and after that I started feeling week again, sometimes tingling, very thirsty all the time. Cannot sleep because of muscle vibrations. Its really bad :( How long did it take your symptoms to go away completely?
Helpful - 0
Avatar universal
Hi how are you feeling? Any news?
May I ask how long did you take the vitamin b6 and how much? I started taking it 3 weeks ago ( 50 mg for 2 weeks) and In a few days I felt bad( tingling in feet and arms, brain fog, weekness and after a week it was hard to walk) I stopped taking it a week ago. After stopping taking it i ood for 3 days then I had some alcohol and little sleep and I started feeling really bad. Weekness, fatigue, tingling, thirst, no appetite and hard to sleep because of muscle vibraions. This all feel terrible. Howmlong did your symptoms take to go away???
Helpful - 0
1478335 tn?1287370739
greetings all - hope to learn you are all better. i'm pretty much healed now - took probably 2 years? Still can't eat a lot of potatoes. do get teh dna testing - i cant take methyl anything - that advice was no good for me. extra thiamine and riboflavin alone to help the conversion of the excesss unconverted b6 was very helpful for me particularly early in the process- there was the odd day of a sudden nerve issue due probably to food - spinach was dreadful - something to do with oxalic acid sensitivity in top of the b6.

i found magnesium very helpful in the form of malate orally and espcially the epsom salt as hot bath nightly to bowel tolerance. the sweating very useful and cheap :) saunas when i can get them.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780380116
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