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Best Clinical Trial for Recurrent Stage IV Ovarian Cancer

I have platinum sensitive recurrent Stage IV ovarian epitelial cancer.  I am also positive for a deleterious BRCA2 gene mutation.  There are three clinical trials available to me: a Phase I PARP Inhibitor + Carboplatin Trial, A Phase II Carboplatin + Gemcitabine + Avastin Trial, and a Phase I Carboplatin + Doxorubicin + MORAb-003 Trial.  All are non-randomized.  I would really appreciate any thoughts anyone may have on the potential benefits of the various approaches.  I need to make a decision quickly.  Thank you.
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Avatar universal
Hi,
I'm in the same situation you are, I'm staged 4B epithelial OVCA with mets. to the lymph nodes, and i'm also BRCA2 positive.

I've done debulking surgery,  carbo/taxol, Topotecan and now I'm on Gemzar. The only remission I've had was 4 months after carbo/taxol.

What chemo drugs have you already had, and why did your oncologist suggest you do one of the trials now?

I hope you get lots of responses, it will help all of us in this unfortunate situation.
Jane
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880919 tn?1265465203
I have reading  that PARP inhibitor drug olarparib research is very promising, see the link http://news.bbc.co.uk/2/hi/health/8116790.stm. Also you may check member profile Burrows, who have been in this treatment for 2 years
My best whishes
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