I think it would be worth a try to slow down the infusion and watch her very close. Since the number dropped so much I would hate to give up on a winning drug without another attempt. Of course I am no Doc, but you could ask the Doc. Good luck. Marie
I had a similar reaction to carboplatin in April. My Dr. now uses a desensitization procedure and I have continued to receive carbo without difficulty. I'm sure there are different protocols but mine is as follows:
20 mg oral Decadron night before chemo
20 mg oral Decadron morning of chemo
50 mg oral Benadryl morning of chemo
I believe I receive the usual IV premeds: decadron, zantac, kytril, benadryl
The carboplatin is infused VERY slowly over about 8 hours. The amount of drug and the rate are gradually increased throughout the infusion..
I should also add that prior to going on the carboplatin, I was on Taxol, alone, for 2 years and it was very effectivie. As you know, with this disease, we are all different and it is a matter of finding what works for the individual. There are many options and I hope your mum is able to find something that will work. Please let us know what happens!