Granulosa Cell Tumours

[sdjc206]

Hi There,

Does anyone know much about Granulosa Cell Tumours?  A family member has just been diagnosed with this.  There is not alot of information on the internet about this , so would greatly welcome any reponses about this.
Cheers
Ruth

[scoutshadow]

My first tumour was sixteen years ago and although big (19cms) was still encapsulated - was well but feeling very bloated, couldn't finish a meal and had menstrul irregularities.  I was 29 years old with no children and so had fertility sparing surgery.  I had menstrul irregularities (no periods) previous to this, but after the op they returned.   I had close follow up treatment and had three children.  At ten years I was told that the tumour no longer posed a threat.  

Following the birth of my 3rd child at 40 my periods never returned.  Six years later I had an op (July 06), to remove an ovarian tumour - had severe pelvic pain periodically and an UTI - for two years previous to this.  A fibrous nodule (7cm) was removed (from the scar and adhered to the bladder) and within this was a GCT.   A seedling from the first tumour.  Periods returned again and have not stopped.  I didn't have a TAH then.  

Now unfortunately I'm scheduled for another op in 11 days for what seems to be another recurrence (but I didn't have any symptoms this time caught early on CT scan).  Have occasional bad kidney pain.  They say it is ovarian and is invading the uterus and bladder with ureter involvement.  This is scary as it has grown to 6cm in 3 months, aggressive, and is invasive.  Sorry to end on a negative note.

[sdjc206]

Thank loads for replying, its a reflief to finally find someone with the same thing.  Im not sure what stage it is at as my mom was taken in with suspected apendisitus as she had a lot of abdominal pain.  Once they did an investigation they found the tumour had ruptured and burst , so they removed the tumour, quite big in size and then after the biopsy found it to be Granulosa Cell Tumour.  My mom has a CT scan in two weeks time so check it has all gone.  so fingers crossed.  Is this what happened with you?  did you know it was coming back?  my mom thinks she may of have had a swollen stomach looking back. Hope you dont mind me emailing back , just not alot of info is there.....  

Cheers
Ruth

[scoutshadow]

Hello

I myself have been diagnosed with a granulosa cell tumour.   There is a good article by Chad Mitchner on the internet - just google granulosa cell tumour.  Most tumours are found at stage 1a which has an excellent prognosis as 60% will never see the tumour return in their lifetime.  However it does have a tendancy for late recurrence up to 30 years so I suggest strongly that your relative insist on lifetime follow up.  Don't fall for the 'your past ten years so you are cured' prognosis as I and many others did.  I recurred after 16 years.

I suggest you look through www.ovca.net and click on the Granulosa Cell Tumor forum.  You can go back through the archives.  Another internet link is www.gctf.org.nz which gives access to all the PubMed articles on the tumour and you can leave details of the patient at this forum for future research.  Please check these out.

Hope this has been of help to you.