i just had a granulosa cell tumor removed 2 wks ago. went to gyn onc. and they do not suggest complete hysterectomy and staging, only inhibin levels and ct scans. when they took my tumor out it was 15x14x9 cm and ruptured. i really would like to know if this sounds right to anyone else. everything i have read says a total hyst is needed. oh by the way im 38 and not planning anymore kids. tlrn
the normal results for inhibin A & inhibin B protein tumor markers are different for a premenopausal woman and a post menopausal women (surgical menopause included). So, if you had your both ovaries removed, your numbers would have changed (if you had your inhibin levels tested prior to surgery). Suggestion: Have a PET scan of your abdomen as it will show cellular hot spots if you've got a recurrance or they didn't get it all.
Inhibin A can go up in adrenal adenomas and carcinomas(rare) as well from my reading. I came away thinking that either inhibin A or inhibin B may go up in granulosa cell tumors so that a combined assay like the one at the Mayo Clinic should be used to follow for recurrence.
Thanks xray2u!! I did the same searching, but the info is limited and somewhat contradictory. Some info says we should monitor inhibin A, others say inhibin B, others say MIS. Thanks for taking the time to help!
I did a Google search and there is limited info. I wish I could help you more.