I have written intermittently over the years. In late 2002 I was diagnosed with stage 4 unknown primary (fluid in the lung, collapsed lung –decortication) which was later determined to be Ovarian Cancer. I went through taxol & carbo, then taxol maintanence. After a two year+ remission was treated with doxli for a year+ then carbo again (now allergic) Gemzar (didn’t work) back to Taxol (worked like a charm) a year later had to move on and Avastin was the ticket, stabilized for a year and then added nexavar. 6 months later rising markers dictate a change again. Please keep in mind that my CA 125 is well over 2000 and my 27-29 over 120. They have been pretty high for years now (over 1,000). The confusing part is that my PtCts have been clean. With my markers rising to 2600 and 130 respectively we just did another PetCt this month and the results were the same – clear as ever. My doctor feels that the Avastin is still effective and wants to replace the nexavar (which I have had some toxicity problems with) with low dose 25mg oral citoxin. I was asking about etopiside or even taxotere since I had such good reactions to taxanes in the past. He feels we can save those options. I ddnt qualify for the vaccine study at Roswell. Treating a number is tough but at least on Avastin I feel great am very active and work full time – realy no side effects. Do you have any thoughts on my situation. I think my cancer is an anomaly we might have to think outside the box a little. Thanks so much for your help over the years.