Thank you for your response.
Most of my Mom's disease is located in her pancreas area. She has had blockage to her GB which has caused her continuous nausea, lack of appetite and pain.
At this time we are moving forward with chemo. However, seems Mom has become allergic to the Carboplatin. We are now going to try a desensitization procedure in Atlanta to see if she can receive the chemo that works so well for her.
Do you recommend anyone that would be best to provide this Desensitization procedure?
Thank you again for your time.
stephanie
Hi There
thank you for your question
when you say her symptoms became unbearable, what exactly does that mean?
where is her disease located?
in general I would say she has chemo sensitive disease.
to date , there is nothing as effective as conventional chemotherapy in the treatment of ovarian cancer.
her options include:
doxil
gemcitabine
platinum based therapy using desensitization
there are now many articles on reusing platinum drugs after allergic reactions
here is one link
http://www.sciencedirect.com/science/article/pii/S0090825801963310
while parp inhibitors are scientifically fascinating, the date has yet to confirm any advantage with them. data is maturing and time will tell
here is a link on an ealry phase 2 study
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60893-8/fulltext
as far as antiangiogenesis inhibitors such as avastin,
interestingly, there is very little new data on this since 2006. Most of the fcus has been the use of avastin in primary therapy.
we definitely do add avastin sometimes for recurrence. But there is little new information on its benefit
I know this must be a really hard time for you all
best wishes