My sister (27yrs) was diagnosed ovary cancer stage 1c after surgical removal of cyst in March. She undergone TAHSBO and started Carboplatin for six cycles. But her platelet count is too low and doctor said it is Ok to stop the treatment, so she finished her 5th cycles in August. Now she got a tumor in her abdomen, doctor suggest no surgery and 6cycles of topotecan
Please kindly let me know if it is a right choice not to have any surgery now? Any better option to increase the prognosis? Great thanks.
I am so sorry to hear about your sister. That is a very scary situation. Do you have information on the exact type of cancer that she has?
for instance is it an adenocarcinoma (which is in the category of epithelial ovarian cancer)? or a germ cell tumor? or a sarcoma?
It is very unusual to see a cancer return within a month of finishing chemotherapy.
I am not familiar with how the health system works in Hong Kong. Is it possible to get a second opinion?
Topotecan is a well known drug for recurrent epithelial ovarian cancer (adenocarcinomas such as the subtype serous - this is the most common subtype)
However the leading side effect of topotecan is dropping the blood counts and one of the blood count components is the platelets.
It is also very unusual for a 27 year old on first line chemotherapy to have low platelets.
Does your sister have any other medical conditions such as malnutirtion, hepatitis, HIV, or other infections?
Finally, have other family members had breast, uterine, or ovarian cancer? Age 27 is very young to get epithelial ovarian cancer. Could your family have a genetic risk of getting these caners? if so, other family members such as yourself should be checked by pelvic ultrasound. Your sister should have gene testing to look for a mutation that is hereditary.
I have pasted a few links for you to look at.
Thanks for your reply
She does not have any medical conditions.Apart from low platelet count and low wbc count, she can sleep, eat,no vomiting,no hair loss during last chemo. Any possibile reasons cause low platelet count on her first line chemo?
Actually,my uncle got breast cancer and my dad got cancer too. If my sis really got those genes ,does it mean it is harder to cure if she got cancer ?
Lastly, are there anything we could do to improve the platele count to help her finish this chemo ?
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