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Could meds go arye?

Has anyone ever had a severe reaction mentally to Cymbalte, Neurotrin, and trazadone used togethrer to treat CRPS?  Does anyone think it is possible that someone without a history phyiatric disorders that thee drugs may induce one?
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1403754 tn?1327998912
I have an app on my phone called Epocrates. I use the interaction checker for my mom and I's meds, because you just never know. I ran a check on the ones you listed and came up with the interaction between Cymbalta and trazodone - it says there is an increased risk of serotonin syndorme.

Some of the symptoms of serotonin syndrome are:
Cognitive effects: headache, agitation, hypomania, mental confusion, hallucinations, coma
Autonomic effects: shivering, sweating, hyperthermia, hypertension, tachycardia, nausea, diarrhea.
Somatic effects: myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor.

I hope this information helps. I would talk to the doctor about changing one of the meds or at least lowering the dose of one of them.
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Avatar universal
I asked our Dr. who did not stress negative effects and said teh pros would outweigh the negatives and at firdt it did.  But as the meds strength increase so did sid eeffects.  Noone even the pharmacist told us how the trazadone can make you SOOOOOOOOO nausea.  The weight loss dramatic.    
The doctors keep telling me the med salone couldn't make her feel this way but no history of anything before them and then she loss all ipulse control-says it made her feel like she was out of control and the thoughts she felt wouldn't go away.  Getting treatment to get off all meds now.  Think we'll go back to alternative meds-Tens unit is best friend right now.  Maybe try accupuncuture.
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547368 tn?1440541785
Hell Jfrog,

Welcome to the Pain Management Forum.

There are no physicians or pharmacist on this forum. I think that a pharmacist can best answer your question.

Everyone system can and often does respond differently to medications. Cymbalta can affect one's mental status on it's own. When you combine these medications the impact can be more pronounced.  So even a interaction checker as Jaded so astutely suggested may not take into account that these meds can provoked a different response in individual cases.

If you are asking because you are on these medications please check with your pharmacist. And by all means these concerns should be brought to the attention of your physician.  

Cymbalta is an effective medication for most ppl. However it did not produce the desired therapeutic results when it was prescribed for me. After a short time I had to quit taking it. I know others that do take Cymbalta and achieve great results. Again when are all different.

Best of luck to you.
~Tuck
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Avatar universal
I looked up a drug interaction tracker and found one here:
http://www.drugs.com/drug_interactions.php
I then put in your meds and I found this, although I'm not sure if this link will work for others:
http://www.drugs.com/interactions-check.php?drug_list=2228-0,949-2273,1147-677

Basically what I found is that the Cymbalta and the Trazodone can interact to cause Seratonin Sydrome.  Now that I have actually experienced and it made me extremely emotional and feel like I was going crazy.  The Seratonin Sydrome I experienced was brought on by a different combination of meds, and I don't know if that makes a difference or not.  You're definetly not alone in feeling the way you do, though, and hopefully when you get the meds straightened out you will be back to normal shortly.

I would definetly recommend checking the interactions for yourself and calling your doctor to let him know how you are feeling.  I hope you're back to feeling like yourself in no time.  Best of luck in dealing with this.  Please let us know how it goes!

Ps.  You probably already know, but we're not doctors on this forum, just people who deal with chronic pain who support eachother and answer questions to the best of our knowlege.
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Avatar universal
Have you tried using an interaction checker to see if any or all of them have any interactions?  If you have them all filled at the same pharmacy they are supposed to check for interactions, but sometimes they don't.  The doctor is also supposed to know of possible interactions between medications but due to a number of things like different doctors prescribing different meds for the same patient and some doctors just overlooking or not knowing about interactions, sometimes we have to check for ourselves.
I'd say the best thing to do is to consult your pharmacist and ask if there is an interaction.  You can also just google it.  Personally, I have taken a few of those, but not together so I don't know from experience.
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