I have had knee and elbow pain for years, possibly resultant of many years of horseback riding and injuries. About 12 years ago I had a bout of tendonitis in both arms ( I owned and walked 2 Great Danes daily and did lawn mowing, tree and shrub trimming). I have suffered with this is greater and lesser degrees over the years, depending on what I am putting my body through. About 5 years ago I began having pain and weakness in my thumbs. The pain radiates into my elbow area and even seems to be triggered by certain positions. This morning I awoke with pain and clicking in my right thumb. Additionally, there is swelling in the thumb and a soreness into the heel of my hand (where thumb connects to hand). I am taking meds for migraine/stroke (Plavix, verapamil, lasix, lisinopril, along with thyroid replacement therapy and some allergy prescriptions. I've been on these meds for years) One med that is fairly new for me (started about 3 months ago) is Serrapeptase, a non-presription enzyme for joint pain that my doctor has okay'd. Any ideas about my joint pain and "new" thumb issue?