I agree, she does not seem to be a TMAU, but rather a PATM patient to me. I know a few people with PATM who have similar odours, as described by her in the video, it does not look like she was ever tested for TMAU and the doctor that has "diagnosed" her seems to have pulled this diagnosis out of thin air.
This doctor is a GP, not a metabolism or any other kind of specialist AND he has been asked to provide with a diagnosis for the TV show - this show might be just as big of a thing for him as it is for her, so in the end he just wants to appear competent.
Why did they choose him and not some specialist is a good question, but what would any specialist say about her symptoms is even a better question. She says she makes people rub their noses, their eyes water, they cough, they sneeze! As we all know very well, in the eyes of 99.999% of doctors anyone with PATM has ever seen - that's just crazy talk. :) But hey - we got some mainstream TV exposure in English! I think that's a first!
Look at the following interview, this is exactly what I was trying to describe earlier in my post. Ray was trying to describe the same thing earlier, he believes it's most likely an enzyme deficiency. The last two sentences are important. The scientist is explaining that other conditions like TMAU may exist and it could be two possibilities 1) unusual gut flora 2) lack of a detoxifying enzyme (liver enzyme).
Ma Mr Nigel Manning, Principal Clinical Scientist
Dept. Clinical Chemistry
Many people, including people with primary or secondary TMAU diagnosis, as well as those who are negative, have wide ranging odors. From gas/fecal to rotten egg and all sorts. Do you have a theory on this ?
“Body odour is caused by the release of volatile compounds from the skin in sweat. Just as TMA is produced in the gut by bacteria, there are probably many other volatile compounds which are naturally produced – like skatole which has a faecal odour. Only when the production of these compounds are produced in excess that the odour can become a problem. There may be other conditions like TMAU which are caused by an unusual gut flora as well as a lack of a detoxifying enzyme. Unfortunately we only have the ability to test for TMA at the moment.”
Wow! Look at this. TMAU2 kid cured by antibiotics alone. I guess the kid had no resistance because he didn't use antibiotics before so it was easy to kill off the bad gut bacteria.
Secondary TMAU only seems to be tested in the UK that we know of. Why do you think this is so ?
"Secondary TMAU or TMAU2 has been recognized for many years, although much of the TMAU interest has been in the inherited metabolic disorder FMO3 deficiency ie TMAU1. Very early on in the TMA service I received a urine from a pre-school age boy who was very odorous after eating fish. This was especially problematic because fish fingers were his favourite food and his parents had to persuade the parents of his friends to not serve fish fingers at birthday parties. The prospect of this going on when he started school was worrying, but after finding out about TMAU the parents arranged for the test to be done here. When I saw the very high TMA and TMO I suggested to the GP that a short course of the antibiotic metronidazole might help. After this dose this 4 year old had no more problems and could enjoy fish and chips with his family with no resulting odour – and still does ten years on. His TMAU had been cured and it convinced me that TMAU2 was an important part of the differential diagnosis.
TMAU2 from overproduction of TMA by bacterial overgrowth can be experienced for many years but if the correct antibiotic therapy is applied, can be cured by eradication of the bacterial responsible. Testing for TMAU1 or 2 is essentially the same, but results can usually differentiate one from the other. As I mentioned before there have been several occasions when a patient with marked increases in both urinary TMA and TMA-oxide (a TMAU2 pattern) then tests positive for TMA but with normal TMA-oxide (a TMAU1 pattern). This is why the DNA follow-up is so important."
MEBO recommends vitamin B supplement to maximize FM03 production. Second, activated charcoal - helping to remove toxins. They make activated charcoal derived from coconut which you can add to gluten-free banana breads, almond butter etc. Odorless TMAU is well documented in medical literature, its possible that we have this is some form.
Imo, you don't need a clinical lab test to see if have TMAU. Yesterday I had Poke, Hawaiian/ Japanese food with tons of Tuna (high in foline) to see what would happen. My digestion is still wacky today. If your body responds adversely to high foline foods (broccoli, salt-water seafood, peanut butter) its likely TMAU is at least part of the PATM puzzle.
Someone on the TMAU forum said they have literal FMO3 enzymes you can buy from a lab in Europe. I'm not about to take these but its interesting to know something like this exists.
w w w.abcam.com/FMO3-antibody-ab62178.html
This is very promising because it has medical community behind it. I myself feel PATM is very similar to TMAU like most of us do but we describe it as odorless TMAU.
However I was at a site one time and the person said there is a smell in here, I can't smell it when i'm in here but if I leave and come back I can.
I’ve just read paper where a person had both TMAU1 and TMAU2…lol. Believe it or not, it is possible. What scientists found is that she had mutations on her FMO3 gene which flags her as having a partly functional liver enzyme (TMAU1) but the TMA urine test also show she had elevated TMA but normal TMA/TMAO ratio (TMAU2). They gave her antibiotics to lower the gut microbial overgrowth and TMA production went down but came back up again after a while…lol. Nature can be tricky.
So we’ve seen PATM, TMAU2, TMAU1, PATM+TMAU2…. and now TMAU1+TMAU2.