Completely different..my first pregnancy was a girl and it was easy! This second time its a girl but this pregnancy has been rough for me, sick a lot and very uncomfortable, low iron and such.
My second has been way better than my first i had a girl and was sick the entire time this one is a boy had a little morning sickness in the beginning but it was gone right into the second trimester a little more pain in my hips this time but been a way better experience :)
Alot worse then the first, everyone is different though there is no telling how your going to handle your pregnancy for the 2nd time.