Do calcifications cause PSA to rise? My PSA has consistently risen over the last few years from 1.95 three years ago to 2.4 last year and 4.0 this year. I have had some ED issues, which prompted some of the testing in the first place. He said that half the men my age (young 50s) have ED problems and basically implied don't worry about that. Dr performed a DRE and found a nodule, followed by an ultrasound and found calcifications. Volume was 27 (so PSAD around 14%?). Free PSA around .53 (ratio around 13%?). He opted not to biopsy but said follow-up in six months. I've seen that prostatitis and BPH can raise the PSA, but haven't read anything about calcifications causing the rise. Is he expecting the PSA to level off or decline in six months? 27 doesn't seem "enlarged" to me anyway.