Thank you for your response, I have another questions, my pathology report indicated that my surgical margins were negative with additional findings indicating high grade prostatic intraepithelial neoplasia,small focus left side.
would this cause my PSA reading to go up and down.
High grade prostatic intraepithelial neoplasia (HGPIN) in fact a precursor lesion to development of invasive prostatic adenocarcinoma (Prostate Cancer).
Given that you had a prostatectomy, one wouldn't be led to believe that the presences of HGPIN would cause a variation in your PSA. But it may be telling of the extent of your cancer which may in turn affect your prognosis.
Again, it is important to follow you PSA regularly with your urologist after treatment.
Thank you for your question.
Ashutosh (Ash) Tewari, MD
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