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PCA3 Plus false positive

I recently had a PCA3 PLUS score of 69.2.
The test specs claim an accuracy of 71%.
A 12 needle biopsy indicated no cancer what-so-ever.

What's the real story on this test, and what are the real odds for a score of 69.2?
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242579 tn?1252114771
Thank you for your question. A low level of PCA3 is expressed by normal prostate cells. The PCA3 score tells the expression of PCA3 corrected for the presence of normal or BPH epithelial cells. Therefore, your PCA3 urine tests results are actually a ratio of PCA3 to PSA mRNA. In your case, a high PCA3 score could either mean 1) a high presence of PCA3 or 2) a small level of normal or BPH tissue in the specimen. Interpretation of the results, that is the probability of a positive biopsy, is dependent on the particular assay used.

Normal transrectal ultrasound biopsy (TRUS) samples a very small percentage of the prostate gland. A PSA rise, with negative biopsy and elevated PCA3 would warrant close attention with repeat psa, dre, and biopsy.

Kind regards,

Ash Tewari, MD


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