Thank you for your question. I am not sure what you are referring to with respect to the "attentive 3 stroke procedure." A rectal exam or prostate massage is performed to order to increase the amount of prostate cells secreted into the urine. Upon urination the cells are collected and analyzed for the presence of PCA3. Prostate cancer cells tend to make much more PCA3 than normal cells. A PCA3 level above 100 has been shown to result in a positive biopsy over 60% of the time.
An elevated PSA along with a positive PCA3 test may point towards prostate biopsy.
Thank you for your question.
Ash Tewari, MD
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There is limited data in the literature on effect of a UTI on PCA3. There is no evidence that the test would change PCA3 results.
Thank you for a prompt response. Three stroke attentive DRE are not my words; I think I read this on the USRF website.From your response and whatever else I could read up upon, it appears PCA3 test is more used to confirm High PSA and/ or previous negative biopsies. Also, is it true that the presence urinary infection could make the PCA3 score higher; for this reason, some doctors do this test after prescribing antibiotics to clear up any infection prior to the test?