I am a 43 year old man who was recently diagnosed with COPD, specificaly Emphysema. I first began using Spiriva about a year ago with a severe upper respiratory infection/Bronchial infection, and noticed that every now and then, my tongue swells up. The swelling seems to be mainly the bottom of the tongue and feels bruised before and during the swelling, at the base of the tongue. I have heard that this could be a possible side effect of Spiriva, but can't find the info anywhere. At first I thought that the swelling was an alergic reaction to food, but when Benedril did not reduce the swelling and Ibuprofen did, I had to rethink it. If this IS a reaction, do I need another medication? If so, what other option is there? By the way,The swelling seems random, only happening occasionaly.