Most of the studies use oral retinoic acid. Retinoic acid in an animal model of emphysema has been shown to restore air sacs, also called alveoli. This is a very promising therapy.
Vitamin A in large doses can be toxic to the liver so high doses should be avoided. Until we know more from the results of the ongoing studies, using a Vitamin A supplement with no more than 100% of the recommended daily dose would be reasonable.
I have been reading the articles about the clinical trials using retinoic acid,they sound very promising. My father is 88 and has had Emphasema for 25 years .He has always taken at least 10,000 iu's of vitamin A, sometimes more. I believe this might be why he is still doing fair for his age & condition. He has been taking about 50,000 iu's at this time because we have been reading about retinoic acid. The doctor is keeping tabs on his liver function and all is well.I am certainly not a doctor but I would suggest going to a health food store to get natural vitamin A. Also many times you can find a very health informed owner who is willing to answer all of your questions. I know people who have taken theraputic doses of vitamin A (100,000 iu's), for a short while with no ill effects, but if I used that much I would certainly have my doctor monitor my liver function. < Hope this helps >
Vitamin A (like many supplements) can have VERY TOXIC effects if taken in high doses, so it is strongly DISCOURAGED as a medication to take in substantial quantities. Please discuss this with your doctors if you have any questions. I believe they are trying different methods of delivering the Retinoic Acid, to minimize the side effects & determine the therapeutic dose that has the best results with the fewest side effects. The studies I have read have indicated they are trying several forms of retinoic acid, to see which one has the best results.
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Starion
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I have been reading the articles about the clinical trials using retinoic acid,they sound very promising. My father is 88 and has had Emphasema for 25 years .He has always taken at least 10,000 iu's of vitamin A, sometimes more. I believe this might be why he is still doing fair for his age & condition. He has been taking about 50,000 iu's at this time because we have been reading about retinoic acid. The doctor is keeping tabs on his liver function and all is well.I am certainly not a doctor but I would suggest going to a health food store to get natural vitamin A. Also many times you can find a very health informed owner who is willing to answer all of your questions. I know people who have taken theraputic doses of vitamin A (100,000 iu's), for a short while with no ill effects, but if I used that much I would certainly have my doctor monitor my liver function. < Hope this helps >
I have emphysema and I have cancer . If any one has a suggestion on helping me to breathe please let me know. Or if you know where to obtain Retinoic Acid . Please help. ***@**** please send replies that will help me !
Thanks for your responses. I have been taking multivitamins for over 20 years. For over 10 years it has been Centrum which lists the vitamin A at 100%. As I have developed emphysema, obviously 100% isn't enough, if one is exposed to second-hand smoke. I am too young (49) to "just accept" my diagnosis without a fight. I refuse to suffer as an innocent bystander to other people's smoke and am determined to find something that will help. I have just gotten over a bout of Bronchitis and am already getting worse again. I am willing to try anything. I need to find out a safe upper level for the vitamin A.
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