I have had a ongoing excessive sinus drainage for over 2yr. now. I have lupus and recently 2mo ago had ethmoidectomy and deviation correction to help manage the problem. Unfortunately it really hasn't helped ,now I get a constant stream of spit like maybe a little thicker, flow down the back of my throat. YUK! it's 24 - 7 I get very little sleep since I'm up coughing out mucus, anyhow, my question is this . My rheumy who saw me 2days ago gave me a depo-medrol shot to see if maybe that would help calm the sinus problem. How long should I wait to see if it is working? I notice no change as of today Sunday. He also prescribed diflucan 100mg for 14 days if medrol didn't help. I'm just not sure how much time I should give the medrol shot before realizing it is or isn't helping. I am desperate for some relief any help is appreciated. Thanks