Dear Dr,
I am a male in my thirties and have had an inflamed urethra for 12 weeks. The only definite symptom is a (sometimes more red and sometimes more blue) inflamed tip of my penis which has been constant for the 12 weeks and I have tested negative for clamydia, gonnerhea, hsv, hpv, hiv, syphilis, and a uti as well as positive for a uti and nsu over the 12 weeks. The latest test last week showed no uti but showed ten wbc from a penis swab so obviously still inflammation present. It hurts after masturbating and urinating but is only red and sore and the rest of the time I barely notice it. Over this time I have taken azithromizing one dose, metronidizole one dose, nitrofuaretoin low dose for 5 days, oxytetracycline 7 days and ofloxacin 7 days.
I have now been given (by a UK Dr) three courses to try (and he said there is little treatment left after this): Doxyclycline 100mg twice for 7 days, a longer course of Azithromycin for 5 days and a longer course of Metronidizole for 5 days. He said I needed to take Metronidizole with one of them but it was up to me which!
1 I also bought fluconazole single dose to take in case it is thrush?
2 Would you suggest I take the Metrondzole with Azithromycin or Doxyclycline? Is there any evidence on this and is there a synergy between drugs or do they all work in isolation to each other?
3 How much should I space out these treatments?
4 I want to retest, and maybe do online tests for mycoplasma and ureaplasma, but how how do I need to wait after my last does of Oxfloxacin?
Would be extremely grateful for your advice.