I don't think anyone on this forum is likely to have any experience with this drug for M gen or any opinions about it. Or quinupristin (Synercid®).
M gen causes only about 10% of NGU. As best is known, it's pretty much harmless, especially for men. No complications of M gen have ever been reported in men -- no known urethral stricture, epididymitis, infertility, etc, only urethritis itself which is typically mild. Its role in causing serious disease in women remains a matter of uncertainty, but but most studies suggest it's not a major player in PID, infertility, etc -- not nearly as important in this regard as gonorrhea or chlamydia. Probably the large majority of M gen infections never cause symptoms, and for sure most infections are never diagnosed or treated, and clear up on their own. I cannot imagine it is worth the time and expense to travel internationally to get some new drug for it. And while moxifloxacin resistance may be common in some parts of Australia, it appears to be effective in most geographic areas.
As for any drug not being "allowed" for treatment of certain infections, that reflects a misunderstanding. In the US, Synercid might be approved by the FDA only for staph and strep, but once a drug is on the market and approved for any particular purpose, it can be prescribed for anything at the prescribing provider's discretion. (The only exceptions are for narcotics and other drugs with addiction/abuse potential.) Few docs would agree to it for an infection for which it has never even been studied, like M gen, and whether your insurance would cover it is a another matter. But there are no legal restrictions if you can talk your doctor into it.
I have experienced epididymitis, prostatitis, back pain, and pain down my legs. I also have it in my throat which is causing chest pains and dull headaches. I have been on Moxi for a little over a week now and it doesn't seem to be helping much at all. I have been fighting this for over 3 months now and my local doctors have been of no help whatsoever and have had to do all the research myself and present it to them for treatment as they had never heard of it. Therefore, if I have to spend a few grand to take care of it once and for all, it would be money well spent before it starts to affect my job.
Pristinamycin isn't a new drug, it has been around forever, but since you have to take 4,000 mg a day (2x500 x 4 times a day) it hasn't been as widely used as all the other drugs that only require one or two pills a day, thus the lack of resistance to it.
"I have experienced epididymitis, prostatitis, back pain, and pain down my legs." I remain skeptical you have really had all these (professionally diagnosed) and that M gen is the cause of any of it.
After going round and round with my primary care doctor who couldn't believe that 3 weeks of doxy wouldn't have cured my ailment, I have been seeing a urologist who is working with an infectious disease specialist. So, who should I be talking to instead?
In general, ID specialists are far more likely to be knowledgeable that urologists about infections, antibiotics, STDs in general, and M genitalium in particular than most urologists -- even for infections that primarily involve the genitourinary tract.
I'm in similar condition. Completed a 14-day Avelox treatment, discharge seems to be gone, but uncomfort sensation lingers for 5 weeks now.
Start getting uncomfort feeling on my left testis and the left butt and leg.
Where could you get Pristinamycin?
We can not tell you where to get medication.
Interesting information on the study
What your doctors should be doing is lab testing for resistance to specific antibiotics as different strains of m.genitalium post resistance to different antibiotics. Instead it just sound like they are throwing whatever they can at it that has been shown to treat it without knowing which mutations for resistance your mycoplasma has. I received the traditional Azithromycin treatment (1g) and it failed. Then I read studies that Avalox was supposed to be a 100% cure and it failed for me - the infection came back 3 weeks later. Then I had to see another doctor and he put me on the long term dose of Azithromycin which I knew would fail but they wouldn't listen to me. Luckily I found a doctor that would listen and I did a 21 day treatment of Doxycycline with the hopes that my type of M. genitalium would not have resistance and luckily it worked. More than likely you will need a long term dose of antibiotics that the m. genitalium is not resistant to due to the replication rate of mycoplasma (which is 21 days) I hope this helps.
My infection with m.genitalium was certainly not harmless. I had reactive athritis due to it. I also had extremely painful urination and discharge. There were also major side effects from the anti-biotics I took trying to get rid of it.
Much of the current research on NGU, Prostatiis and PID is actually pointing at m. genitalium as a cause when patients tests negative for other traditional infections and m.genitalium is quickly gaining attention for it's ability to mutate and form resistance to all anti-biotics.
Thanks for the info. I was on Avelox for 14-day and I have not had discharge for over 7 weeks now. And the MG DNA test from urine is also negative.
However, I have symptome of chronic prostatitis, but doctors are not seeing any actual infections, and told me I should not be on AB.
Initially I had doxy for 3 weeks, but the UTI just came back after 2 weeks. I think a lot of people are as desperate as I am.
Can more people share their experience or methods to alleviate the symptoms?
Mycoplasma Genitalium is horrific. I can't understand why more isn't known or published about it. It just doesn't clear up like Chlamydia does. Why is there not more noise about it!?
Looking across MedHelp you can see the threads that start off with 'I had unprotected oral' and are largely left unanswered. With hindsight it's obvious that Mycoplasma is behind it. I'm hoping that those folk got cleared up ok in the absence of knowing what they really had.
M Gen needs far more exposure. It's #3 in the U.S. and no-one is crowing about it.
I have been diagnosed by myco g and have been on doxy first for 14 days then 28 days then tried azithromycin for 5 days then a longer 3 week course. Still no effect. Then got on moxifloxacin for 10 days. Symptoms got worse after day 5. Symptoms are pain in the left side of stomach and back pain. Very slight pain/discomfort in penis which is hardly noticeable. Did start out with discharge but this has gone away. Main problem is pain in lower left side and discomfort in back area which seems to be moving up my back. Going on for a year now. Just been prescribed Pristinamycin so heres hoping.
How did this treatment go? Same boat!
Hey May1203. no good. the pristinamycin was going well after day 3. but after i finished symptoms returned after a couple of days. Just had another test but the symptoms are still there. Don't know whats next.
Hey Ashton. Did the Pristinamycin kill the Mycoplasma?
Have you had a new test after the treatment?
did u retest for ur MG?
how are you right now?
can u share?
Hi Guys, has anyone from the US been able to get their hands on pristinamycin?
Update: I took a trip to France and saw a doctor there, which cost about $100 to have one come to your hotel room. Took the Pristinamycin and some steroids as prescribed which was about another $100. Symptoms went away for 2 months but came back briefly for a month then went away for good. I think there is a lot of validity to the fact that you shouldn't focus on it too much and carry tension in your pelvic floor thus aggravating the issue. I kept taking tamsulosin for several months then eventually quit taking that as well. Glad to put it behind me. No guarantees it works for anyone else, but worked for me. I guess if you have a couple thousand to spend, hop on a plane.
Update: Went to Paris, had doctor come to my hotel room for $100. Got Pristinamycin and a steroid prescription, another $100. Symptoms disappeared after taking meds but reappeared for a month then disappeared completely. I kept taking Tamsulosin for several months. I think there is a lot of validity to the statement that you shouldn't think about it too much and carry all of that pelvic floor tension, which only makes matters worse. No guarantees, but I have been issue free for over a year now. Glad that is all behind me now.
Update: I ended up taking a 5-day course of moxifloxacin. My symptoms remained about 2 weeks after, and during that time, my appointment with an infectious disease specialist finally came. My urine was tested for Mycoplasma and Ureaplasma DNA, which came back negative, leukocytes indicated I was not fighting an infection. My symptoms faded over about 2 weeks after completing antibiotics. Never did confirm what I had but overall, my symptoms were milder than what most are reporting. I never had a substantive discharge, only evidence (split urination from dried discharge in the morning, staining on inside of underwear) and a discomfort in my urethra (not burning pain while urinating). Symptoms still come back occasionally, but are very mild (just urethral discomfort).
I'm not 100% clear on what the cause was, but I suspect it may have been from marijuana withdrawal (after ~15 years of daily use), which coincided with insomnia and cognitive difficulties. Occasional marijuana use brings back these symptoms, as well as the mild feelings of discomfort in my urethra. However, original discharge symptoms appeared several days after having sex with a new partner, who was also sleeping with someone else at the time, and had several symptoms (minimal vaginal lubrication, miscarriages), which may have indicated PID.
In summary, its a mystery, but moxifloxicin seemed to have worked. Be very careful about straining joints and ligaments on azithromycin/moxifloxacin.
Hi. If your reading this then I assume you think you have Mycoplasma genitalium. I had it for 2 years and so I will share my story and how I finally cured myself. Btw trichomoniasis is a similar condition so please have a chat with the doctor so you can go in the correct direction.
After a 1 night stand and doing some anal I found out I had discharge and so went to the clinic. I was told it was a ngu, which means it could be anything apart from gonorrhoea. Btw gonorrhoea is now getting totally resistant to antibiotics so please do always wear a condom because gonorrhoea is agony. I will always wear condoms from now on because these diseases are getting dangerous.
So anyway, the doctor advised me to take doxycycline for the usual dosage as opposed to azithromycin which is the preferred treatment in America. After 2 years of research I would say that the NHS is correct in using doxycycline for now as it doesn’t promote antibiotic resistance compared to azithromycin which does, If you have just been diagnosed with MG then I would ignore both of these and go straight for moxifloxacin because both of these only has around a 40% cure rate. Many doctors who are worth their salt are now going for this method and as someone who has tried all of these, I would do this method. You can buy all of these 3 online using something like https://www.doctorfox.co.uk/. You don’t have to declare anything to the doctor on here so no record on your doctors computer.
All of these 3 methods failed for me and part of that reason is because of bacteria load. I researched for 2 years and gained a lot of knowledge on this. In clinical trials there has been evidence showing that having a low bacteria load is usually the difference between failure and success.
After more research and speaking with 2 consultants I decided to try something called Pristinamycin. It is not registered in the UK but it is in France and one or two other countries. The consultant had never heard of it so I had to show evidence that it was tolerable. After finding the information that he needed, he wrote a private prescription and I got it in Lloyds pharmacy albeit after they had to ring around a few places to find it. It cost me nearly 600 pounds. Gulp.
At this point it had been almost 2 years and so it was time to go to battle with this stubborn *****. The antibiotic resistance problem is very real so I had to prepare in advance. I concluded that to lower my bacteria load, I had to use a combination of diet, pills and supplements. First I bought doxycycline again but this time it was only used to lower the bacteria load. I did a 10 day course of 200mg twice a day. As the consultant advised I also had to improve my gut bacteria and so used the activia or yacult drink and also a gut bacteria supplement called pro ven which contains 25 billion cultures. I also used myco herbal supplement, bee polen, zinc, garlic, turmeric and muli vitimins. This lot along with special foods (which I will mention) started at the same time as the doxycycline prior to taking the main drugs – Pristinamycin and minocin 10 days later. So the foods I had were a yogurt drink called kefr and kimchi (disgusting) which really improved my gut bacteria and oddly enough, my skin. I ate raw cranberrys and cranberry juice which is good for fighting infections. I stayed away from all sugars . For my main meals I had sweet potato, jacket potatoes, haddock fish, lentils, veg and anything organic. No tea, coffee, chocolate, sweets or anything like that, only green tea and cranberry juice. So after 10 days I started the Pristinamycin and minocin. I had no reactions apart from a little diarrhea. I had 1g twice a day of Pristinamycin and 100mg once a day for minocin together with the doxycycline and all the supplements mentioned. No reactions as I’ve mentioned but I was nervous because taking 3 antibiotics isn’t for the faint hearted.
For many days after the course was finished my penis was swollen and as the consultant told me, it was like taking domestos bleach so its understanable. Interestingly this 3rd consultant told me that for a few years after a strong treatment, the nerve endings inside the urethra can tingle giving false messages to the brain and so she gave me some cream to relax the nerves. Its called clotrimazole.
I hope nobody has to go through all that but at least it may help someone with my personal experience.