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Discharge, drip and Urethritis, but no STD

So I started having unprotected sex with girl #1.I thought I felt a little urethritis about a week after we first started having sex, and when I peed it kind of sprayed, so I went to get checked.I also had a slight drip that looked like pre ***.The results came out negative. I then have unprotected sex with girl #2.I then go back to having sex with girl #1. A couple weeks later, my urethritis and drip gets even worse and I start to have full on discharges.I get tested yet again, and I bring girl #1 with me. She's had absolutely no symptoms. She was even examined and the doctor said she looked fine.We both get Doxycycline and I feel better.Tests were negative.I then continued to have unprotected sex with girl #1 and everything is normal.A couple months later I start having sex with girl #2 again. Soon after having sex with her I start to get that drip again. (I had sex with #2 many times four months before #1 and was totally fine)So I go to the doctor yet again, get tested, get Doxy, feel better, and get negative test results.They said since I tested negative I could have sex with her again.She was not treated.I have sex with girl #2 yet again, and the drip and discharges come back with a vengeance, the worst its ever felt and this was only a couple days after I had sex with her again.SO AGAIN, I go back to the doctor, bring girl #2 with me. We're both treated with Doxy and I get tested yet again.She's positive for HPV, but we're negative for anything else. I stop having sex with girl #2.Unfortunately, this time after taking the doxy, the symptoms did not totally go away. I had urthritis, and when I urinated it still kind of sprayed.I then have sex #2 again, and all the symptoms came back, and doxy doesn't seem to totally get rid of the symptoms.What should I do?It's been going on for 6 months now and my testicals have a slight pain. I've seen a urololgist and he seems stumped.I feel like I may need a different anti-biotic and a higher does.What do you think? Help!
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239123 tn?1267647614
MEDICAL PROFESSIONAL
Welcome to the forum.

You describe a somewhat confusing situation, and I'm not sure I understand the sequence of different partners and their treatment.  Your symptoms are highly suggestive of recurrent or persistent nongonococcal urethritis (NGU), which by definition isn't gonorrhea and is rarely caused by chlamydia -- so it isn't surprising your routine STD tests are negative.

However, the only treatment you mention is doxycycline.  Were no other treatments tried?  The standard approach, as recommended by CDC and other agencies, is that when NGU persists or recurs after doxycycline, azithromycin should be given (and vice versa -- if persistent after azithro, doxy is given next time).  In addition, it is now recommended that metronidazole or tinidazole also be given, to cover the possibility of trichomonas, which can be difficult to diagnose, especially in men.  For continued persistence or recurrence thereafter, the drug moxifloxacin (Avelox) is sometimes used, to cover the possibility of an infection with Mycoplasma genitalium, which can be resistant to both doxy and azithromycin.

So if doxy is the only treatment you have had, you should now be treated with azithromycin (1.0 g, single dose) and tinidazole (Tindamax, 2.0 g single dose) (or metronidazole, but it's probably less reliable than tinidazole).  If these have been tried, discuss moxifloxacin with your urologist or other doctor.  Also, it would be wise for both your partners to be treated similarly, if that hasn't been done.

You might consider discussing this thread with your doctor(s), or maybe print it out for them. In case they are interested in seeing the guidelines, they can be found at http://www.cdc.gov/std/treatment/2010/default.htm

Let me know how it all sorts out.

Regards--  HHH, MD
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A related discussion, The Clap or Chlamydia? was started.
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A related discussion, What to treat my partner with. was started.
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