It could be one of the two things:
1. Testicular cancer (You mentioned on your inner thigh, assuming on the testicles or near) - But this is possibly less likely considering you didn't mention the bumps being on the testicles.
2. STDs
Talk to your doctor about STDs for you and your wife, and if you feel it's necessary, talk to your doctor about testicular cancer as well.
Hi Jones, Are these new or have you had them for some time, have you treid anything on them, creams? its either stop scratching them, or stop moving around.
End of the day need some more info.
Good Luck