I am a 59 yeaar old male who has battled insomnia for 20 years. In the last 2-3 years it has become debilitating. I am at a point where sleep is impossible without medication. Napping is very rare. If I do manage to get to sleep, at night, ( never before 11:00 pm) I will wake up within 30-45min. and remain awake all night. I have read about Alpha Wave Intrusion and I would bet this is what I have. Unfortunately, most doctors have very little experience and education with complex sleep issues and resort to writing meds. I had a sleep study 6 years ago. No apena, less than 100 minutes of sleep
( out of 360) and REM time under 30 min. I have tried everything including acupuncture, brain music, herbal remedies and most of the drugs on the market.
About a year ago, I went to a psycharist for generalized anxiety disorder and was started on Lexapro ( 10mg) Unfortunately, one of the major side effects is insomnia, which just componded my sleeping issure. The Lexapro help greatly in the diminishing the GAD but I just could not exist with 45 minutes of sleep a night. I was taking Lunesta 3mg prior to the Lexapro for 1 1/2 years. With the Lexapro, the Lunesta was ineffective. The MD put me on 15mg of Remeron with the Lunesta and this really helped.
In an attempt to ward off tolerance to Lunesta, I now alternate ( 2 weeks at a time) between Lunesta 3mg and zolpiedem ( Ambien) Since the zolpiedem has a much shorter 1/2 life than the Lunesta, I take 5mg about 11:30 and another 5mg at 3:00 or whenever I awake. The Lunesta usually allows for 6-7 hours of continuous sleep. The initial sedating effects of the Remeron lasted anly about 2 weeks but in combination with either one of the hypnotics, it seems to be helping, now 9 months later
So, the questions I have are: Do any others take Remeron with one of the above mentioned hypnotics? Can this medication combo be continued on a long term basis? Is the 2 week at a time duration sufficient to keep from becoming tolerant to zolpiedem and Lunesta? I realize they are both in the non benzodiazapine hypotnic classification, but does anyone know if they are different enough in structure to use like this?
I am just trying to get by until a new classification of sleep medication gets to market. There are 2 drugs in late stage clinical trials that target a completely different receptor in the brain from the current hypnotics.