I write this somewhat desperately.
At age 41 I had a total thyroidectomy (in 1998), and for 12 years, was placed on Synthroid .125. Despite being fit and optimistic for most of my life, I was dead feeling and exhausted. No surprise that every endo I went to, said my labs were "in range" and chalked it up to "depression" or "age" related. Finally my endo at the time added 5 mcg cytomel, and I felt great! After bloodwork 6 months later, she became alarmed, told me to go off of cytomel, because "You could have a stroke, and I could be sued". Two years ago I found an excellent physician who prescribed Naturethroid, and dosed according to my symptoms (2 grains) while also periodically checking labs for thyroid hormone, including FREE T3. I felt wonderful for those two years! In the last 6 months things have gone completely haywire. It seems that somehow I have developed an allergy to Naturethroid. I was switched to a compounded T3 only, in (I believe) a much too high of a dose to begin with (60 mcg per day), but I didn't know that at the time. After several days, I began having frightening hyperthyroid symptoms and almost went to the ER, for fear I was having a stroke. At first the compounded T3 seemed to work well, and I felt relief from the allergy symptoms (which included ringing in ears, shortness of breath, dizziness, blocked ears, stuffy nose w/ yellow drainage, cough, tingling on one side of body), until the high dose overwhelmed my system. Then (in my opinion) I became hypersensitive to compounded T3. I am unable to take even the smallest amount of it now, because I have tingling on one side of my body, shortness of breath, palpitations, etc. They reduced my thyroid meds completely, and have "started over" - on Synthroid. Using the 50 mcg tablet, because of no dyes, etc. I began with 25 mcg for 4 days. Increased to 50 mcg for 4 days, etc. I am now on 100 mcg. I have to take an allergy pill in the morning, and Benadryl at night to keep the allergy symptoms hardly at bay. I am already experiencing the familiar depression, anxiety, lethargy and exhaustion that I had for 12 years. This time there seems to be no alternative because of my reactions to all the other available thyroid hormone options. Since I don't have a thyroid gland, taking nothing is not something I can consider. Has anyone had a similar experience? I would be so grateful for any help you can offer.