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Anemic levels and low Vit D
Hello,
I've had fluctuating levels for anemia and Vitamin D. The D was in severe range at one testing, and some years later, someone thought to test it and it is now in insufficiency range. The anemic values are currently normalized on their own.
Does anyone here know why that would be? Are these issues common with adrenal and thyroid issues?
Thank you.
I've had fluctuating levels for anemia and Vitamin D. The D was in severe range at one testing, and some years later, someone thought to test it and it is now in insufficiency range. The anemic values are currently normalized on their own.
Does anyone here know why that would be? Are these issues common with adrenal and thyroid issues?
Thank you.
COMMUNITY LEADER
This is a very old thread and you'd probably get more attention, if you post a new one........ you can do that by clicking the orange "Post a Question" button at the top of the page, type in your question, then click the green "Post a Comment" button.
That said, we have to know the reference ranges for all of those tests. Ranges vary from lab to lab, so they have to come from your daughter's own report.
MCH is Mean Corpuscular Hemoglobin. Hemoglobin's job is carry oxygen to the blood. "A low MCH indicates an iron deficiency whereas a high MCH results in too much hemoglobin present which causes insufficient supply of oxygen to the blood."
An elevated MCH blood test result (high levels) indicates macrocytic anemia due to paucity of folic acid or vitamin B12 or thyroid problems.
That said, we have to know the reference ranges for all of those tests. Ranges vary from lab to lab, so they have to come from your daughter's own report.
MCH is Mean Corpuscular Hemoglobin. Hemoglobin's job is carry oxygen to the blood. "A low MCH indicates an iron deficiency whereas a high MCH results in too much hemoglobin present which causes insufficient supply of oxygen to the blood."
An elevated MCH blood test result (high levels) indicates macrocytic anemia due to paucity of folic acid or vitamin B12 or thyroid problems.
Need to clarify my daughter test results the doctor as well as when she donated blood in 2009 said that she was anemic. and I thought it was iron deficiency, She has taken yearly blood test since 2008 and these are the results. this time the doctor said that she is anemic but when I said that the result show her iron is just above boarderline according to australian standards, how come she is anemic. She then said it is her MCH, and MCHC by .3 to.5) could someone expalin it to me a bit in detail after going through all the results and how to rectify it. Some article mentioned that if your have liver problems you should not take iron tablet is it true. They also said that after a barium scan that she had some patchy calcification in liver JUne 2012, Septemebr 2010 nothing about calcification in liver noted, blood result seem normal for liver function.Thank God, her MRI said that calcification is better seen on scans and study normal. the oral barium liquid that she should have taken acertain dose one hr and the following dose in the next hour. She tooK about 35 mts for the first dose that needed to be taken and another 45 mts before she finished the 2nd dose and her test was done about 1/2 hour later, could this cause an hindrence on the scan.
Her blood test results are as follow Australian standards, that was taken on 1/6/12 Note previous Docotors said slighly anemic, never explained it, I thpought it was it was iron deficinecy, but this GP said iron is in normal range to boarderline but still slighly anemic on MCH and MCHC (.3-.5), iron studies show
Ferratine since 2008- 17,2010-24,, 2011-30, 2012 -25,
Iron 2008 -9, ’2010- 7, ’2011-25,2012-8,
Transferrin-2008- 3.0,’2010- 3.1,’2011- 2.9, ’2012-3.2,
Transferrin Sat-2008- 12, ’10-9. ’11-34, *’12-10% (not sure why % as the others did not have them)
folate and B12 normal,
(* for been anemic due to the following
*MCH 26.7pg,
*MCHC-21.1g/dl, and low in Vitamin D
HB 13.1,
PCV42.1%
RCC 4.91×1012/L,
MCV 86fl, White cell count 10.7,
Neutrophils 66%, Lymphocytes,
19%, Monocytes 8%,
*Esonophils:7%, high due to allergies hayfever
Basophils:0%,
Platelets:335,
thyroid normal
;Serium Biochemistry reslults inluding
billirubin 5 umol/L,
cretine 62 umol/L,
sodium 141
potass 4.3mmol/L ,
chloride 108 mmol/l,
bicarbonate 25mmol/l,
urea 5.0mmol/l
EST.GFR > 90 per 1.73 sqm,
ala aminotransferas 15u/l ,
Asp. aminotransferase 17u/l,
alkaline phospates 74 u/l,
gemma glutamyl trans GGT 10U?L ,
total protein 75 G?L
Albumin 46 G/L,
Globulin 29G/L, Dr said they are in normal range ),
did Coeliac Disease serology (serium) – normal 2.53 as she had bloated, gassy, cramps above belly button and lower part of chest with severe pains, that she had on 14th may for 3-4 hrs and the next day which she never mentioned anything as well as the same pains on the 29th where the docotr at emergency siad IBS and sent us home pains continued and went to local GP gave buscopan injection which relieved sypmptom in less that 10 mts while still at the doctor and asked to take 2 gavascon siad that it might not have anything to do with the calcification, she started to get the bloated feeling took gavascon and it was relieved about a week or two after, got the bloated feeling took gavacon and it helped, thats why scan was done and also because she complained about on and off stitch like pains on left side, since 2010, in which 2010 ultralsound nothing noted all clear, 2012 scan with oral barium noted patchy calcification on 1/6/12
.
Just need to clarify if anyone knows how to rectify the MCH,MCH please note read somwhere that if you have liver problems you should not take iron tablets is it true I presently give her Vitamin D1000IU and Centrum Advance, which she takes beofre going to bed even though it states to take VIT D after meals and she doese not take it everyday either
Her blood test results are as follow Australian standards, that was taken on 1/6/12 Note previous Docotors said slighly anemic, never explained it, I thpought it was it was iron deficinecy, but this GP said iron is in normal range to boarderline but still slighly anemic on MCH and MCHC (.3-.5), iron studies show
Ferratine since 2008- 17,2010-24,, 2011-30, 2012 -25,
Iron 2008 -9, ’2010- 7, ’2011-25,2012-8,
Transferrin-2008- 3.0,’2010- 3.1,’2011- 2.9, ’2012-3.2,
Transferrin Sat-2008- 12, ’10-9. ’11-34, *’12-10% (not sure why % as the others did not have them)
folate and B12 normal,
(* for been anemic due to the following
*MCH 26.7pg,
*MCHC-21.1g/dl, and low in Vitamin D
HB 13.1,
PCV42.1%
RCC 4.91×1012/L,
MCV 86fl, White cell count 10.7,
Neutrophils 66%, Lymphocytes,
19%, Monocytes 8%,
*Esonophils:7%, high due to allergies hayfever
Basophils:0%,
Platelets:335,
thyroid normal
;Serium Biochemistry reslults inluding
billirubin 5 umol/L,
cretine 62 umol/L,
sodium 141
potass 4.3mmol/L ,
chloride 108 mmol/l,
bicarbonate 25mmol/l,
urea 5.0mmol/l
EST.GFR > 90 per 1.73 sqm,
ala aminotransferas 15u/l ,
Asp. aminotransferase 17u/l,
alkaline phospates 74 u/l,
gemma glutamyl trans GGT 10U?L ,
total protein 75 G?L
Albumin 46 G/L,
Globulin 29G/L, Dr said they are in normal range ),
did Coeliac Disease serology (serium) – normal 2.53 as she had bloated, gassy, cramps above belly button and lower part of chest with severe pains, that she had on 14th may for 3-4 hrs and the next day which she never mentioned anything as well as the same pains on the 29th where the docotr at emergency siad IBS and sent us home pains continued and went to local GP gave buscopan injection which relieved sypmptom in less that 10 mts while still at the doctor and asked to take 2 gavascon siad that it might not have anything to do with the calcification, she started to get the bloated feeling took gavascon and it was relieved about a week or two after, got the bloated feeling took gavacon and it helped, thats why scan was done and also because she complained about on and off stitch like pains on left side, since 2010, in which 2010 ultralsound nothing noted all clear, 2012 scan with oral barium noted patchy calcification on 1/6/12
.
Just need to clarify if anyone knows how to rectify the MCH,MCH please note read somwhere that if you have liver problems you should not take iron tablets is it true I presently give her Vitamin D1000IU and Centrum Advance, which she takes beofre going to bed even though it states to take VIT D after meals and she doese not take it everyday either
My MPV is low-normal. I just read that "If your MPV shows up too low, it may be an early indicator of bone marrow cancers like leukemia." Any cause for concern, considering my frequent fluctuating blood issues?
I'm looking at my records:
Birth bloodwork...
*18.1 RDW%
3+ aniso macrocytes
1+ polychromasia
My physical this year:
4/2010 CBC w/differential
RBC 4.09 L [4.20-5.40]
MCH 31.6 H [27.0-31.0]
RDW 12.9 % [11.5-14.5]
Hematocrit 37.1 % [37.0-47.0]
MPV 7.3 [7.0-11.0]
Birth bloodwork...
*18.1 RDW%
3+ aniso macrocytes
1+ polychromasia
My physical this year:
4/2010 CBC w/differential
RBC 4.09 L [4.20-5.40]
MCH 31.6 H [27.0-31.0]
RDW 12.9 % [11.5-14.5]
Hematocrit 37.1 % [37.0-47.0]
MPV 7.3 [7.0-11.0]
As for megaloblastic anemia, this is what they said:
"MCV 99.3 HIGH (I read this means you are okay as far as iron deficiency goes)"
High MCV might eliminate Iron deficiency, however it is an indicator of B12 and/or Folate deficiency!!!!
Mean Corpuscular Volume (MCV)
drkaslow's website
The MCV relates to the average size of the red blood cell. MCV increase or decrease along with an increase or decrease in MCH is a significant finding for folic acid and/or B12 need (INCREASE) or iron, copper or vitamin B6 need (DECREASE). MCV and MCH should always be viewed together.
Optimum values 87.0 to 92.0 cu. microns.
The MCV is increased in:
Hereditary anemia(s).
==>>-Megaloblastic Anemias (Pernicious, FOLIC ACID deficiency, B12 deficiency)
-Reticulocytosis (acute blood loss response; reticulocytes are immature cells with a relatively large size compared to a mature red blood cell)
-Artifact (aplasia, myelofibrosis, hyperglycemia, cold agglutinins)
-Liver disease
-Hypothyroidism
-Drugs (anti-convulsants)
Zidovidune treatment (AIDS)"
"MCV 99.3 HIGH (I read this means you are okay as far as iron deficiency goes)"
High MCV might eliminate Iron deficiency, however it is an indicator of B12 and/or Folate deficiency!!!!
Mean Corpuscular Volume (MCV)
drkaslow's website
The MCV relates to the average size of the red blood cell. MCV increase or decrease along with an increase or decrease in MCH is a significant finding for folic acid and/or B12 need (INCREASE) or iron, copper or vitamin B6 need (DECREASE). MCV and MCH should always be viewed together.
Optimum values 87.0 to 92.0 cu. microns.
The MCV is increased in:
Hereditary anemia(s).
==>>-Megaloblastic Anemias (Pernicious, FOLIC ACID deficiency, B12 deficiency)
-Reticulocytosis (acute blood loss response; reticulocytes are immature cells with a relatively large size compared to a mature red blood cell)
-Artifact (aplasia, myelofibrosis, hyperglycemia, cold agglutinins)
-Liver disease
-Hypothyroidism
-Drugs (anti-convulsants)
Zidovidune treatment (AIDS)"
COMMUNITY LEADER
Megaloblasitic/pernicious anemia, is characterized by larger than normal red blood cells (macrocytosis) usually determined by RDW, (which I don't see on your list of labs) and low vitamin B12 levels. Megaloblastic anemia is also often characterized by low folic acid levels - I don't see that on your list either.
With macrocytosis, the red blood cells are larger than normal; anisocytosis is when the red blood cells are excessively unequal in size.
With a B12 level of 833 (range 239 - 931) and no folic acid test or RDW, I'm not sure how someone came to the conclusion that you have megaloblastic anemia. I would be interested in knowing, as I want to make sure I understand the issues, both for myself and for future members who might have a similar situation.
I have pernicious anemia and even on weekly shots, I have a hard time keeping my B12 levels as high as yours.
Anemia due to iron deficiency is not the same thing.
With macrocytosis, the red blood cells are larger than normal; anisocytosis is when the red blood cells are excessively unequal in size.
With a B12 level of 833 (range 239 - 931) and no folic acid test or RDW, I'm not sure how someone came to the conclusion that you have megaloblastic anemia. I would be interested in knowing, as I want to make sure I understand the issues, both for myself and for future members who might have a similar situation.
I have pernicious anemia and even on weekly shots, I have a hard time keeping my B12 levels as high as yours.
Anemia due to iron deficiency is not the same thing.
A forum poster said Megaloblastic anemia (B12, Folate, and possibly iron)
Below from late 2007/early 2008:
Ferritin 15.3 [ref 6.2-137.0 ng/mL]
RBC COUNT 3.49 LOW [REF 4.2-5.4]
Hemoglobin 11.8 LOW [REF 12.0-16.0]
HEMATOCRIT 34.7 LOW [REF 37-47%]
MCV 99.3 HIGH [REF 81-99]
MCH 33.9 HIGH [REF 27-31]
-----------------
1/08:
Vitamin D, 25-OH, Total: 7ng/ml LOW [ref 20-100]
Vitamin D, 25-OH, D3: 7ng/ml
Vitamin D, 25-OH, D2: <4ng/ml
_______________________________________________
12/07:
RBC: 3.76 LOW [ref 4.0-5.2M/UL]
HCT 36.8 % LOW [ref 37-45)
MCH 33.5 HIGH [ref 27-33 pg]
EO % 5 HIGH [ref 0-4]
-------------------
Date 4-13-10:
B12 833 pg/mL [239-931]
Ferritin 52 ng/mL [6-132]
Sodium 142 mmol/L [137-145]
Potassium 4.4 mmol/L [3.5-5.0]
Creatinine 0.7 LOW mg/dL [0.8-1.5]
Globulin 2.2 LOW g/dL [2.3-3.5]
Date 8-21-10:
FT4 1.13 ng/dL [0.60-2.19]
TSH 2.17 uIU/mL [0.47-4.68]
Date 4-13-10:
FT4 1.22 rest as above
TSH 3.86 rest as above
Date 4-13-10:
CBC normal except...
RBC 4.09 LOW M/uL [4.20-5.40]
MCH 31.6 HIGH pg [27.0-31.0]
?MCV 90.7 fL [80.0-97.0]
Date 4-13-10:
Vitamin D, 25 OH Total i 28.3 ng/mL <<===== this is the "a little low" my doctor commented on.
(Insufficiency 10-29 ng/mL)
Old, Date 6-29-00
Iron 133 [28-170]
Iron Binding Capacity 432 [260-490]
My infant bloodwork looks abnormal. The one done on birthday says "aniso macrocytosis" and "poly chromasia"
I can see my RBC were below range on several infant days. MCV high out of range. MCH high out of range.
It's driving me crazy how my CBC cells keep going back and forth; normal, then abnormal! Oy vey!
Thank you. :)
Below from late 2007/early 2008:
Ferritin 15.3 [ref 6.2-137.0 ng/mL]
RBC COUNT 3.49 LOW [REF 4.2-5.4]
Hemoglobin 11.8 LOW [REF 12.0-16.0]
HEMATOCRIT 34.7 LOW [REF 37-47%]
MCV 99.3 HIGH [REF 81-99]
MCH 33.9 HIGH [REF 27-31]
-----------------
1/08:
Vitamin D, 25-OH, Total: 7ng/ml LOW [ref 20-100]
Vitamin D, 25-OH, D3: 7ng/ml
Vitamin D, 25-OH, D2: <4ng/ml
_______________________________________________
12/07:
RBC: 3.76 LOW [ref 4.0-5.2M/UL]
HCT 36.8 % LOW [ref 37-45)
MCH 33.5 HIGH [ref 27-33 pg]
EO % 5 HIGH [ref 0-4]
-------------------
Date 4-13-10:
B12 833 pg/mL [239-931]
Ferritin 52 ng/mL [6-132]
Sodium 142 mmol/L [137-145]
Potassium 4.4 mmol/L [3.5-5.0]
Creatinine 0.7 LOW mg/dL [0.8-1.5]
Globulin 2.2 LOW g/dL [2.3-3.5]
Date 8-21-10:
FT4 1.13 ng/dL [0.60-2.19]
TSH 2.17 uIU/mL [0.47-4.68]
Date 4-13-10:
FT4 1.22 rest as above
TSH 3.86 rest as above
Date 4-13-10:
CBC normal except...
RBC 4.09 LOW M/uL [4.20-5.40]
MCH 31.6 HIGH pg [27.0-31.0]
?MCV 90.7 fL [80.0-97.0]
Date 4-13-10:
Vitamin D, 25 OH Total i 28.3 ng/mL <<===== this is the "a little low" my doctor commented on.
(Insufficiency 10-29 ng/mL)
Old, Date 6-29-00
Iron 133 [28-170]
Iron Binding Capacity 432 [260-490]
My infant bloodwork looks abnormal. The one done on birthday says "aniso macrocytosis" and "poly chromasia"
I can see my RBC were below range on several infant days. MCV high out of range. MCH high out of range.
It's driving me crazy how my CBC cells keep going back and forth; normal, then abnormal! Oy vey!
Thank you. :)
COMMUNITY LEADER
Are you anemic, as in iron deficient? Or anemic, as in vitamin B12 deficient.
You said your vitamin D is "now" in the insufficiency range - what is the actual number? And how long ago was it tested? Same for the anemic values? These are tests that need to be done periodically, not just every few years. Additionally, like thyroid values, just being "in range" doesn't mean that's normal for you.
I have pernicious anemia and even with B12 levels in the 500's (range 200 - 1100), I feel like crud, but get them above 800 or so and I'm okay. I take weekly shots to keep my levels up.
We all have our "comfort level", whether it be thyroid hormones or other things.
If you have current results, it would be great if you could post them, along with reference ranges. This would help us comment more fully on your particular situation.
You said your vitamin D is "now" in the insufficiency range - what is the actual number? And how long ago was it tested? Same for the anemic values? These are tests that need to be done periodically, not just every few years. Additionally, like thyroid values, just being "in range" doesn't mean that's normal for you.
I have pernicious anemia and even with B12 levels in the 500's (range 200 - 1100), I feel like crud, but get them above 800 or so and I'm okay. I take weekly shots to keep my levels up.
We all have our "comfort level", whether it be thyroid hormones or other things.
If you have current results, it would be great if you could post them, along with reference ranges. This would help us comment more fully on your particular situation.
You'd be surprised to know that most of the general population has low Vit D levels.
Anemia has many forms and some are inherited, some right themselves and some need supplements.
It seems common that many thyroid patients have low ferritin and low Vit D levels, but the same can be said, again, for the general population with no thyroid issues.
Just one of those things!
Anemia has many forms and some are inherited, some right themselves and some need supplements.
It seems common that many thyroid patients have low ferritin and low Vit D levels, but the same can be said, again, for the general population with no thyroid issues.
Just one of those things!
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