These are the deiodinases...D1 which converts T4 to T3 peripherally, D2 which converts T4 to T3 in the pituitary, and D3 that converts T4 to RT3.
D2, which is found only in the piruitary converts T4 to T3 for the exclusive use of the pituitary. D2 (5'-deiodinase) is what my pituitary lacks and why my TSH is permanently high. I believe D2 just converts more efficiently than D1...it doesn't have anything to do with lack of competition from D3.
"The pituitary cells are able to use the thyroid in the blood maybe more efficiently because it has no enzyme that wastes some of the thyroid at RT3." Don't forget that the production of RT3 has a beneficial function in the human body. It's the body's way of protecting itself by lowering cellular T3 levels in times of crisis, such as malnutrition, starvation (including some weight loss programs), severe infections and metabolic or malignant diseases.
However, it's obvious that even under these extreme conditions, the pituitary cannot affort to be starved for T3 like the peripheral tissues can.
Yes. I believe that is the general enzyme name. Then after reading further says that there are at least 3 different types or variations of the enzyme. It further stated that the pituitary is the ONLY tissue in the human body that did NOT have D3. In other words, the pituitary is totally blind to RT3. The pituitary cells are able to use the thyroid in the blood maybe more efficiently because it has no enzyme that wastes some of the thyroid at RT3. Or at least that is what I got out of the article.
Looking back I think I may have linked up the wrong article with the discussion of the D1, D2 and D3. I've also have seen articles calling them by different names with primes and such.
I will have to try to refind that article. I thought I had book marked it.
Are you referring to the diodinases?
I think it is related to the enzymes that convert the T4 into T3 and to RT3.
My reading has basically come to the conclusion that there are three different variants of this enzyme. D1 converts T4 into T3 but is pretty inefficient. D2 does the bulk of the work converting T4 into T3. D3 however converts the T4 into Reverse T3.
So it seems possible if this is true, that a person could have very low D2 enzyme levels or too high of D3 enzyme levels or even a combination. In that case, a person would have lots of thyroid T4 in the blood but not converted into T3 or too many converted into RT3. Leaving you feeling Hypo.
You said that you felt pretty well at one point and at that point your labs looked good with FT3 and FT4 as listed here:
TSH .027 (.35-5.5)
FT4 1.38 (.61-1.76)
FT3 3.8 (2.3-4.2)
You stated:
"I think I was actually feeling better at this point, but because my doc was a TSH watcher, she started lowering my dose and that began my downfall of feeling horrible."
Too bad you didn't have an RT3 level at that point.
I wonder if there isn't something going on with the enzyme levels of the various types.
Here is a link to an article which is technical but seemed to explain this stuff. It is the first article that I've found in this depth.
http://nahypothyroidism.org/thyroid-hormone-transport/#conditions
Look under the heading "Conditions associated with abnormal thyroid transport"
Hope this can provide some help to your plight.
Donpodiochi, I have told my doctor several times and shown her articles, but you can't force a doctor to change his/her mind if they don't want to. My labs aren't normal. They're too low, but because she's only looking at the TSH, she thinks I"m overmedicated. She does go by symptoms, but also goes by labs. I haven't felt well being on any dose, so that's what's puzzling all these docs.
Tell those stupid doctors that you have a pituitary problem so obviously they cant use TSH.
A thyroid doctor should get you in normal ranges after that they should medicate by symptoms not numbers.
The last doctor I saw said my levels are normal and if my next TFT is normal she will send me to a psychiatrist.
My thyroid problem started 6 months ago I have never had anxiety,or any mental problems in my life,I just know I don't feel normal yet.
Just because a thyroid patient's lab scores are normal they are not necessarily normal for each individual.
doctors are stupid...when it comes to thyroid prooblems...
I didn't find a doc who tested for RT3 until I was on thyroid meds for about 3 years. When I finally had it tested, it was very high, so maybe the T4 took a while to build up or something. I also could have had adrenal issues back from the beginning and didn't know it, so maybe at first I felt better on T4 meds, but after a while they may have stressed out my adrenals. Who knows. Whenever my RT3 was too high, my FT4 and FT3 were also high, so it didn't look like I was having a conversion problem, but I really was. It's just very confusing to me how I could be taking all these meds for years and even when the labs look good, I still feel hypo.
The last posted labs (0.27, 1.38, 3.8) look great. You should have been feeling well.
"I think I was actually feeling better at this point, but because my doc was a TSH watcher, she started lowering my dose and that began my downfall of feeling horrible. "
I think you hit the nail on the head.
Furthermore, your FT3 to FT4 balance was excellent on a T4-only med. I don't see any kind of conversion problem here.
Here are labs when my FT3 was at its highest and so was my RT3.
TSH .004 (.35-5.5)
FT4 1.43 (.61-1.76)
FT3 3.4 (2.3-4.2)
No RT3 tested
TSH .006 (.45-5.5)
FT4 1.59 (.82 - 1.77)
FT3 4.7 (2.0-4.4)
RT3 406 (90-350)
Still very hypo with both labs
These are labs right before I started thyroid meds:
TSH 3.73 (.35-5.5)
FT4 1.01 (.61-1.76)
No FT3 tested
Labs after being on probably 50mcg synthroid for only 3 months. See how quickly my TSH gets suppressed on only a T4 med.
TSH .027 (.35-5.5)
FT4 1.38 (.61-1.76)
FT3 3.8 (2.3-4.2)
I think I was actually feeling better at this point, but because my doc was a TSH watcher, she started lowering my dose and that began my downfall of feeling horrible.
Yes, I did the 24 hour saliva test. Another doctor suggested taking the seriphos. I can only take one, otherwise it lowers my cortisol too much by morning. My doc said to only take 1mg melatonin. She said if you take too much it can lower your body's own cortisol or something like that and mess it up. She said to try it for a week and if I'm still waking up during the night or feeling tired in the morning to go back on 5mg HC.
I've mentioned to her about treating the adrenals first. I just think this doctor is all over the place and now she's more focused on this alternative weight loss program she started. She thinks that it's also my diet and told me to get a juicer and go on a juice fast for a few days. I know it's not that since I've had hormone problems since I was a teenager.
Oh, and I have had my Vitamins and minerals tested. I was a little low in Vit. D so I'm taking 5000ui a day. I don't have IBS. I stopped eating gluten and dairy a year ago.
My doc is saying to try a juice fast to clear out my system and jump start my immune system. I can't afford a juicer though and I still think this is all hormonal and not what I eat since this all started when I was a teenager and has just gotten worse since starting the thyroid meds 4 years ago.
Talk to your doctor about it; everything I've read says to deal with adrenals first, then thyroid.
Did you do a 24 hr saliva test, for the adrenal dx? Is the seriphos prescribed by your doctor?
I tried taking melatonin before bed, even 3 mg was too much and left me feeling groggy and zombie-like in the morning; 1 mg didn't keep me asleep all night.
I'll post my labs tonight. I have low cortisol in the morning and slightly high at night. I take seriphos at night. My doc wants me to try melatonin at bedtime first and then try HC in the morning. So maybe lowering my thyroid meds is a good thing if my cortisol is messed up??
What adrenal issues do you have and what's being done to treat them? How were they diagnosed?
Adrenal issues should be resolved before trying to work on resolving thyroid function issues.
Sorry I forgot to attach the link that I mentioned in my post above that within it states that TSH is of little value.
http://www.hormonerestoration.com/Thyroid.html
With the seeming "resistance" to thyroid even at higher levels would suggest something else is going on. The idea that the hormone is not getting in to the cells is something that occurred to me. One thing that can do this as mentioned above is reverse T3.
This a a really good site but a little technical that I've found recently. It really gets into the technicalities of the enzyme and the different variation of the enzymes that convert the T4 into T3 and RT3 and help with cellular transmission of Thyroid. Maybe you have some deficiency with one or more of those enzymes or something. Worth trying to find out more by your research and knowledge so you can discuss with your Dr.
However it still comes to mind to me that your body can't absorb or use at the cellular level what is NOT present. Your levels are very, very low in the ranges.
Having hormone present and not having your body utilize them is one thing. But it seems like your not even giving your body a chance because there is so little to even contemplate use.
I'm still baffled by your Dr. KNOWING and acknowledging that your pituitary is messed up but him believing that TSH and thyroid response is NOT affected. That just doesn't make any sense to me at least!
Here's a few more thoughts, Just as one might get irritated for a Dr to say oh your fine it;s something else, might suggest that you do have to look at other stuff. Do you take supplements?How's your Vit D and Selenium? Do you have IBS as that can cause absorbance issues. I used to be really wiped out and discovered that besides being undermedicated,I had really low Vit D and was on too much Progesterone which made me really groggy. Your labs are obviously low but other factors could contribute to the problem as well. Some Drs tend to look at everything individually and not connect the dots We live with ourselves and know best what's going on so we may be better able to put it all together.
This was a great little video about testing and deficiencies
http://www.youtube.com/watch?v=VnE-wPm3nPY&feature=colike
Do you have all your thyroid test results from the time when your Free T4 was 4.4? If so, could you please post them? Also, what meds and dosage at that time?
My RT3 was high for two years when I was using LabCorp. My doc uses Quest and it hasn't been high, so I don't know if my body changed or the labs did. I did notice Quest uses the old TSH ranges.
Forget the last question. I found it above.
One other thing that came to mind is, have you ever been tested for Reverse T3?
Yes, I've had it up to 4.4 and still had hypo symptoms. I had one doc say the meds may not be getting into the cells, but just showing up on labs in the blood. Not sure how to fix that.
You said you have never felt better on any dose. Have you ever even gotten your Free T3 above the middle of its range?
As a good thyroid doctor has said previously, "the dose is irrelevant. The only thing that matters is the clinical response."
My current doc says my pituitary doesn't look like it's affecting my thyroid, but is affecting some other hormones. I never feel better on any dose though (always worse but never better), so not sure what that means.
Thanks! I'll read all those. My TSH before starting on any thyroid meds was first 3.49, then a few years later it was .045, then the next year it went up to around 2, then up to 3.49 when I finally started meds. So not sure what all the up and down means.
And another link.
http://www.ncbi.nlm.nih.gov/pubmed/3122632?dopt=Abstract
In this link, take special note of the following statement.
"A suppressed serum TSH was found in 65% of patients with a normal serum total thyroxine."