What is the reference range for the Free T4? Reference ranges vary lab to lab and have to come from his own report.
If he's over medicated, the medication could make him feel this way. Does he have other symptoms of over medication, such as sudden weight loss, diarrhea, hand tremors, rapid heart rate, etc?
Does he also have a Free T3 result? Those symptoms could also apply to hypothyroidism, which is under medication and could happen if he's not converting the Free T4 to Free T3, which is the thyroid hormone that's actually used by individual cells in the body. Free T4 is a storage hormone and isn't used directly; it must be converted to Free T3. Not all of us convert adequately, which leaves us hypo, in spite of seemingly adequate doses of T4 med.
Without a Free T3 result, we can't really know whether he's hyper or hypo.
The free T4 value is 35 pmol/L. His physician didn't draw a T3 which I have asked for the next lab draw. I'm just not sure if his thyroid med dose is a large contributor of his feelings or not. I think he does have some underlying stress/depressed mood but I have never seen him like this before and he is 46. It will be a year in March since his thyroidectomy. His current endocrinologist seems to only care that his TSH level is near 0 for the first year without taking into account it may be affecting how he feels with all his anxiety....especially when he wakes up.
BTW it seems the normal range for T4 is 9-22pmol/L.
Did your brother have thyroid cancer? If so, it's customary to keep TSH suppressed (at/near 0), following TT). Be assured that TSH neither causes, nor alleviated symptoms, so that's not an issue with your brother's depression/anxiety.
The FT4 and FT3 are the levels we look at to determine if one is over medicated or not and there is no FT3. The FT4 is definitely too high, but whether that's from over medication or because he's not converting to FT3 is hard to say.
How long ago was the dosage dropped from 150 to 125? Your brother should be rechecked 4-6 weeks after that to make sure his FT4 is coming down and make sure he asks for the FT3 test along with that.
If the current endo is unwilling to order an FT3, along with the FT4 and TSH, in order to get the full picture of what's going on, it's time for your brother to find a different doctor.