Are any ingredients in this supplement that may affect TPO Ab?

[Cinnamon16]

So, I'm a 25-year-old man trying to figure out why I had a large variance in thyroid test results between May 2014 and August 2015. My TSH and thyroid antibodies swung wildly high in that time, despite Free T3 and T4 remaining stable. (variance can be seen here: http://i.imgur.com/cHgVotk.png)

I've been analyzing any and all lifestyle/regimen changes in that time, and one of the largest is switching multivitamin brands. The one I've been using (Optimum Nutrition) has a host of ingredients that go well-beyond a normal multivitamin.

So, perhaps this is grasping at straws, but I have read that various supplements and medications can (sometimes) affect TSH and TPO Ab numbers--and I definitely want to rule out any conflicting variables before starting thyroid medication. After all, my numbers were decent last year, and I don't feel any markedly different from May 2014 to August 2015.

Here's a screenshot of the ingredients (I only took two a day, not three; so, for all the numbers listed, I was ingesting 2/3 of that amount): http://www.optimumnutrition.com/products/images/optimen-facts.jpg

Can anyone spot anything that may be problematic?

Thanks!

[goolarra]

In that time period, your FT4 actually went up, and your FT3 remained virtually unchanged.  This would explain why you didn't feel a whole lot different.

Goitrogens can affect your FT3 and FT4 levels by interfering with hormone production.  If FT3 and FT4 go down, TSH should go up, but goitrogens do not affect TSH directly.  Also note that goitrogens interfere with thyroid peroxidase, which is the enzyme that catalyzes the synthesis of thyroid hormones.  TPO is the enzyme, TPOab is the antibody that attacks the enzyme.  

Selenium (200 mcg in your vitamin) is touted by some to reduce TPOab.  

I tend to think the straw came up kind of short!  LOL

TSH will often go up as the thyroid suffers damage and needs more TSH to stimulate it to produce hormones.  It's the same principle that makes FSH go up approaching menopause.  Those ovaries just need the extra kick, and so does the compromised thyroid.

Apparently, you still have quite a bit of thyroid function left.  In my opinion, why take meds just to make your numbers right?  Meds are unlikely to change your TPOab.  Your body will let you know when you need meds, and you're alert to monitoring FT3 and FT4 now.  

[Red_Star]

There are goitrogens listed in that supplement - kale, brussels sprouts, spinach, cauliflower, broccoli.  I wasn't too sure about goitrogens and thyroid antibodies but did find this article from Women to Women which does mention something in regards to this...

Goitrogens And Thyroid Health — The Good News!...

"What is a goitrogen?
Most goitrogens are naturally-occurring chemicals that are ingested in foods or drugs. These chemicals can interfere with thyroid function in different ways. Some compounds induce antibodies that cross-react with the thyroid gland; others interfere with thyroid peroxidase (TPO), the enzyme responsible for adding iodine during production of thyroid hormones. Either way, the thyroid isn’t able to produce as many of the hormones that are needed for regulating metabolism. See my other articles on nutrition and thyroid health for more on how this works.

For people with healthy thyroid function, the thyroid simply compensates and makes more of the hormones as they’re called for. But in some people whose thyroid function is already compromised, the thyroid gland may actually grow more cells as it tries to make up for inadequate hormone production, eventually forming a goiter (a swelling or enlargement of the thyroid gland)."