importance of reverse T3

[sharanbr]

I would like to know the significance of reverse T3 values.

In some articles, it seems to suggest that if T4 is normal but if T3 is low then RT3 has to be measured.

In some articles, it seems to suggest that even if T3 is normal it does not matter as RT3 can bind to cells making reception of T3 inactive.

So, it is not clear if RT3 is significant only when T3 is low or it independently makes any difference

[gimel]

In the link I gave you, item c. on page 5 says, "There is also evidence of RT3 binding to membrane receptors and producing hypo-metabolic effects"  Also, "Excess RT3 seems to be a good marker for reduced cellular T4 and T3 levels not detected by TSH or serum T4 and T3 levels."

So, if RT3 is high and the FT3 to RT3 ratio is less than about 1.8, then there is the potential for RT3 dominance as it is called, which can cause hypo symptoms.  

Have you had a RT3 test?  Or are you speculating that you may have such a problem, due to symptoms.  Where will I find your latest thyroid related test results and reference ranges.  Have you been tested for cortisol?  
  

[gimel]

I think you will find what you want to know about Reverse T3 in item 4c. on page 5, and Recommendation no. 11 on page 12 of the following link.

http://www.thyroiduk.org/tuk/TUK_PDFs/The%20Diagnosis%20and%20Treatment%20of%20Hypothyroidism%20%20August%202017%20%20Update.pdf

[sharanbr]

Gimel,
Thanks a lot. The paper seems to suggest that RT3 is important only if accompanies by low FT3. While I have read that RT3 can bind to cells and make FT3 ineffective.

In my case, I don't know if I should test for RT3 as I continue to horrendous body ache issues and these only continue to escalate as time progresses.