You have Hashimoto's thyroiditis. Ask for free T4 and free T3 tests as well.
One study found 40% with hypothyroidism had a vitamin B12 deficiency. Also autoimmune pernicious anaemia is one of the autoimmune diseases linked to Hashimotos'thyroiditis. This is of particular interest as you mention abnormal papsmear result.
Excerpts from the article When B 12 deficiency causes false cancer scares...
"In addition to increasing your risk of cancer, B12 deficiency can increase the odds that you'll receive an incorrect diagnosis of precancerous lesions, particularly if you're a woman. That's because B12 deficiency causes the cells lining the cervix to become deformed. These cell changes can cause Pap smears to appear abnormal, often leading to additional tests or even to unnecessary surgeries.
Thus, the presence of what appear to be pre-malignant cells in a Pap smear should always lead doctors to include comprehensive B 12 testing as part of the diagnostic process. This should include treating a serum B12 falling in the gray zone."
"This woman was diagnosed with pernicious anemia in July of 2000, began receiving injections of B12, and went back to her OB/GYN for a repeat Pap smear in October. This time, for the first time in eight years, the result was perfectly normal. This doesn't surprise us at all, because her untreated pernicious anemia made the cells irregular in the first place—and treating that disease caused the cells to become healthy again."
Both free T4 and free T3 not in what is considered optimal range (at least 50% of the reference range).
There are quite a number of reasons for high B12 serum including B12 deficiency! Other tests for B12 are homocysteine (my level was 7.3 umol/L from memory after B12 injections). Also, methylmalonic acid (MMA) and holotranscobalamin II (holo-TC).
This is from Chris Kressers article 'What Everyone (Especially Vegetarians) Should Know About B12 Deficiency"...
"Also, be aware that a high serum B12 does not necessarily rule out functional/active B12 deficiency. In fact, I have come to view a high serum B12 in the absence of supplementation as a potential red flag for active B12 deficiency."
From what I've found online..
Levels of serum vitamin B12 may be raised in:
* Frequent consumption of foods high in vitamin B12
* Vitamin B12 supplements/injections, B complex, or multivitamins
* Functional (active) vitamin B12 deficiency
* MTHFR gene
* Polycythaemia Rubra Vera
- Chronic myelogenous leukaemia aka chronic granulocytic leukaemia
- Acute myeloblastic leukaemia
- Acute promyelocytic leukaemia
* Hypereosinophilic syndrome
* Liver disease:
- Acute hepatitis
- Chronic liver disease
- Hepatic coma
* Non-leukaemic leucocytosis
* Chloral Hydrate
* Lab error
I forgot to mention vitamin D deficiency. One study found:
94% of overt hypothyroid Hashimoto’s patients had vitamin D deficiency.
98% of subclinical hypothyroid Hashimoto’s patients had vitamin D deficiency.
86% of euthyroid Hashimoto’s patients had vitamin D deficiency.
To give you an example, my free T4 range is 10 - 20 pmol/L. 50% of the range is 15 pmol/L. My sweet spot is in the 16 range. This is in the upper 50% of the range. Other members here can calculate the percentage your numbers are in the range. There is some math equation to work it out. I hate maths! :)
With Hashimoto's thyroiditis, TSH can be low on one lab test and higher the next. As thyroid cells are destroyed by the antibody attack, excess hormone is released (hashitoxicosis) so you may have hyperthyroid symptoms on and off.
I found this info online from liver basics...
"Visible spots on the liver appear using medical imaging technology (ultrasound, CT scan, MRI, etc.). Normally, the liver has a smooth, uniform appearance in images generated by such techniques. When spots or discolorations appear, this can be a sign of various liver disorders ranging from benign tumors to inflammation to cancer."
I did not have a liver ultrasound with Hashimoto's but my liver enzymes were elevated due to untreated Hashimoto's thyroiditis.
I definitely have the easy heart rate, i get really shaky, chronic fatigue, IBS, when I wake up in the am I feel like I just got hit by a truck, joint and muscle pain, unable to lose weight (I’ve gained 50lbs in the last 4 years, headaches, etc.
I feel like my body is self-destructing lol. I have the 3 spots on the liver. Does thyroglobulin also indicate Graves’ disease? I feel like I have symptoms of both (but no bulging eyes or thick skin on front of lower legs). Maybe that’s just the thyroid going into the hyper state. Is there anything else that you recommend I talked to my dr about getting tested? I’m going to ask for a thyroid ultrasound. thank you again for helping me.
You can have both Graves and Hashimoto's at the same time. I had this myself. Also called Hashitoxicosis...medicine ran out of ideas lol. But hyper symptoms are more intense compared to "leakage" symptoms from Hashimoto's.
I had the pretibal myexedema
(lasted 12 months) but the condition is not common (0.5–4.3% with Graves).
Thyroid peroxidase antibodies (TPOAb) - 90% Hashimoto's thyroiditis, 75% Graves disease.
Thyroglobulin antibodies (TgAb) - 70% Hashimoto's thyroiditis, 30% Graves.
Thyroid Receptor antibodies (TRAb) - 70 - 100% Graves. Some labs will report thyroid stimulating immunoglobulins (TSI).
Lol on the Hashitoxicosis... sounds like they did run out of names. I mean I am overweight and have gained quite a bit for no reason, i eat less then every before. I think I also may need to get more blood work done. What is the functional range of T3 & T4? I really don’t hope I have graves too... but if I look at symptoms of both, I have symptoms of both. So confusing
She minuave another question. I’m going to the doctor a week from Monday and another doctor a week from Tuesday. Any suggestions on the questions that I should ask? I am going to be sonipset if either one of them try and brush this off. And for the record I had mycoplasma I pneumonia for 16!weeks and nearly took my life at the end of 2016 beginning of 2017. It didn’t respond to antibiotics but my doctor insisted I stay on them anyway. I really might lose my temper if he says that 214 TgAb (Range0-114) is normal. I asked for the nuclear antibody test and he wouldn’t let me have that, he didn’t think I had anything wrong with my thyroid and told me to watch my diet. I eat like a bird, I should be a toothpick. So insulting that what I’m telling him isn’t believed.
I finally go to my PCP at 5:15 tonight. I’m preparing myself for what he will say.... are there any specific questions any of you think I should ask? I’m nervous that he is going to blow this off... after waiting 3 weeks
I want to also add that I have been feelin like I am going to pass out lately. Not sure if hashi’s can cause that?!