Avatar universal

High anti thyroid antibodies

I am 29 and had two pregnancy loses. I have Hashimoto thyroidits with elevated Tsh level and very high TPOab (>3000) and TGab (> 200). I am thyroxin sodium since 2012. And my doses have been increased by doctor with the time. Now on 100 mcg per day.
I dont know what to do to decrease my antibodies as doctor thinks that is the reason for my recurrent losses

Is there anyone out there had same problem and now is better and have babies?
Thank you
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Avatar universal
Sorry for late reply

Yes i had done my Tsh, FT4 and FT3 test done by 1st November,2014.

The results are
h TSH     5.99  uIU/ ml    (0.47-5.01)
Free T4  1.57 ng/dl      (0.71-1.85)
Free T3.  3.82 pg/ml     (2.77-5.27)
Helpful - 0
649848 tn?1534633700
It's not the raw number of TPOab and TgAb that counts.  Even if you lower your TPOab by half, you still have the other half doing its work on your thyroid.

It's not the TPOab and TgAb that is causing you to have the miscarriages,either, it's low levels of actual thyroid hormones caused by destruction of the thyroid gland.  Taking adequate amounts of thyroid replacement hormones will get your FT3 and FT4 up to where you need them to be and should allow you to carry a full term baby.
Helpful - 0
1756321 tn?1547095325
Do you have your TSH, free T4 and free T3 results?

A great comment I found online....

"I have Hashimotos Thyroidis and very high TPO levels (>1300 10 months ago where the normal range was 59 ku/l). I have been taking 200g of Selenium per day, in addition l-thyroxin (but the smallest dose, as my TSH are sub clinical). I have also changed my life style quite a lot. Currently my TPO are 550 (normal range 101), so only 5 times higher than normal vs 20 times 10 months ago." >>> http://www.medhelp.org/posts/Thyroid-Disorders/High-TPO-Ab/show/1545417

I saw an improvement of 80 IU in six months (550 IU down to 470 IU) eating about 3 to 4 brazil nuts daily. Brazil nuts are high in selenium (50 to 90 mcg per nut depending on the soil). Studies show 200 mcg daily is used to help lower TPOAb levels  

Compared to the results from another medhelp member, mine wasn't a drastic result but at the time I was eating a very bad diet, didn't exercise, had other deficiency states not to mention I had chronic inflammation from severe insulin resistance. 80 IU looked pretty good considering. :)

After all that, my TPOAb then skyrocketed during my year of hyperthyroidism; hyperthyroidism caused a lot of oxidative stress! Oxidative stress is when there isn't enough anti oxidants to combat free radicals (reactive oxygen species).

Here is some info from Medscape's article Selenium and the Thyroid Gland
Clin Endocrinol. 2013;78(2):155-164....

"Most authors attribute the effect of supplementation on the immune system to the regulation of the production of reactive oxygen species and their metabolites.

In patients with Hashimoto's disease and in pregnant women with anti-TPO antibodies, selenium supplementation decreases anti-thyroid antibody levels and improves the ultrasound structure of the thyroid gland. Although clinical applications still need to be defined for Hashimoto's disease, they are very interesting for pregnant women given that supplementation significantly decreases the percentage of postpartum thyroiditis and definitive hypothyroidism.

In Graves' disease, selenium supplementation results in euthyroidism being achieved more rapidly and appears to have a beneficial effect on mild inflammatory orbitopathy."
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649848 tn?1534633700
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