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HyperParaThyrodism or not?


I also posted a similar question on the sarcoidosis forum but now I realize it might be better answered here:

My wife got blood test results back today: Serum calcium: 2.55; ionized calcium: 1.3 and Parathyroid Hormone (PTH): 6.5.

From this our doctor concludes she does NOT have HyperParaThyroidism.
However she isn't able to tell us what is causing the high calcium and other symptoms and is suggesting to monitor the levels 6 months from now.

If I fill in the above values in this nice iOS app 'Calcium Pro' it tells me it is very likely HyperParaThyroidism.

Any opinions  on who is right?
We are concerned to leave this for another 6 months.

Cheers, Marcel.
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Avatar universal
Hi there,

Thanks a mill for the fast reply and clear explanations!

Cheers, Marcel.
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1756321 tn?1547095325
Calcium and PTH work in a see saw effect. When one is high the other should be low. There will be problems if you see a "broken" seesaw...

High calcium/high PTH (classic diagnosis of hyperparathyroidism)
High calcium/normal PTH (12% with hyperparathyroidism)
Normal calcium/high PTH levels (4-6% with hyperparathyroidism)
Low calcium/low PTH (hypoparathyroidism)

My seesaw was broken lol.  I had severe magnesium deficiency causing hypoparathyroidism.  If your wife is showing symptoms of hyperparathyroidism then it's worth rechecking labwork. Parathyroid website states this on their Advanced Diagnosis page..

"Also remember that calcium AND PTH levels in normal patients are very constant from week to week, measure to measure... while those with primary hyperparathyroidism have calcium and PTH levels that go up and down from day to day, week to week. They are variable.

There is no medical reason to "wait 6 months and get more tests". The patient either has a parathyroid tumor or they do not. The key to making the diagnosis of primary hyperparathyroidism is REPEATED measures of 1) serum calcium, 2) ionized calcium, 3) PTH. Measure them weekly for 2 or 3 weeks and the diagnosis will be clear in almost all cases."
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