Avatar universal

Hypothyroidism and my levels


My wife just received some results that are a bit concerning and confusing.  Her mother had thyroid cancer and she was just told she likely has a problem with her thyroid. Bellow are the results and they seem beyond normal which is causing concern.

TPO Ab >900 IU/Ml  Standard <9 IU/ML

TSH 3rd Gen 45.89 Standard .4 -- 4.50

My wife is 34 years old and we just had our first child 6 months ago.

Can anyone confirm that this is either really bad or really good as far as the results go?

Thank you,
4 Responses
1756321 tn?1547095325
This sounds like postpartum thyroiditis. This condition typically resolves itself within 18 months (if your wife is having symptoms she can go on thyroid medication -
1756321 tn?1547095325
Oops! I posted before I was finished lol. In some cases of postpartum thyroiditis hypothyroidism is permanent though.
649848 tn?1534633700
With TPOab that high, I'd say your wife has Hashimoto's and the condition will not resolve on its own.   These results are neither "really bad" nor "really good"... Hashimoto's is an autoimmune condition in which the body erroneously sees the thyroid as foreign and produces antibodies to destroy it.  It's the # 1 cause of hypothyroidism in the developed world.  

Most people who have Hashimoto's are on replacement thyroid hormones for life.

With TSH at 45.89, was your wife started on a replacement thyroid hormone and has there been a thyroid ultrasound done to determine whether or not she has nodules on her thyroid?  Nodules are very common with Hashimoto's, but it's important to keep in mind that < 5% of all thyroid nodules turn out to be cancerous.  

Were there any other tests ordered, such as Free T4 and Free T3?   If Free T4 and Free T3 were tested, please post those results, with reference ranges.  If they weren't tested, do make sure they get tested next time, and every time, your wife has a TSH test.  TSH is pituitary hormone, not a thyroid hormone and only provides a small portion of the picture of what's happening...
1756321 tn?1547095325
"Although most women with postpartum thyroiditis are euthyroid by 1 yr postpartum, long-term follow-up reveals an increased prevalence of permanent hypothyroidism. Prospective studies have shown a prevalence rate of hypothyroidism of 23% and 29% at 3.5 to 8.7 yr postpartum (28, 29). Progression to permanent hypothyroidism was more common in women who presented with higher TSH levels and higher titers of thyroid peroxidase antibodies in the hypothyroid phase of postpartum thyroiditis (12). The development of permanent hypothyroidism provides further evidence that postpartum thyroiditis is the clinical presentation of preexisting subclinical Hashimoto’s disease (28)."

Postpartum Thyroiditis - The Journal of Clinical Endocrinology & Metabolism, Volume 87, Issue 9, 1 September 2002
Have an Answer?

You are reading content posted in the Thyroid Disorders Community

Top Thyroid Answerers
649848 tn?1534633700
Avatar universal
1756321 tn?1547095325
Queensland, Australia
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
We tapped the CDC for information on what you need to know about radiation exposure
Endocrinologist Mark Lupo, MD, answers 10 questions about thyroid disorders and how to treat them
For people with Obsessive-Compulsive Disorder (OCD), the COVID-19 pandemic can be particularly challenging.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.
These common ADD/ADHD myths could already be hurting your child